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Bio
In the last 20 years, his laboratory has studied every aspect of skeletal biology ranging from development to physiology. His laboratory deciphered the molecular bases of osteoblast-specific gene expression, a work that culminated in his identification of Runx2 as the master gene of osteoblast differentiation. This was followed by the identification of an entire cascade of transcription factors regulating osteoblast differentiation and of Gcm2 as the master gene of parathyroid gland development. In approaching bone physiology Karsenty proposed that there is a coordinated control endocrine in nature, of bone mass, energy metabolism and fertility. The Karsenty lab has verified in the mouse and whenever possible in humans all tenets of this hypothesis. One of them is that bone should be an endocrine organ regulating energy metabolism and reproduction. This led to the identification of osteocalcin as a bone-derived hormone needed for insulin secretion, glucose homeostasis, testosterone secretion by Leydig cells of the testes and male fertility, brain development cognition and adaptation to exercise. Currently his work focuses through the definition of all functions of osteocalcin in understanding why would bone be an endocrine organ.
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Papers共 541 篇Author StatisticsCo-AuthorSimilar Experts
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DIABETESno. 3 (2024): 434-447
Current Opinion in Endocrine and Metabolic Researchpp.100520, (2024)
Danilo Correa Pinto Junior, Isabella Canal Delgado,Haiyang Yang, Alisson Clemenceau,André Corvelo,Giuseppe Narzisi,Rajeeva Musunuri,Julian Meyer Berger, Lauren E Hendricks, Kazuya Tokumura,Na Luo,Hongchao Li,
EMBO Reportsno. 2 (2024): 593-615
Esther Meron, Maria Thaysen,Suzanne Angeli,Adam Antebi,Nir Barzilai,Joseph A Baur,Simon Bekker-Jensen,Maria Birkisdottir,Evelyne Bischof,Jens Bruening,Anne Brunet,Abigail Buchwalter,
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