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My postdoc work at Guy’s and at University of Southern California revolved around analysis of the physical properties of red cells, and later leukocytes, that influence their circulation. On returning to UK and St. George’s Hospital Medical School, I applied these analytical approaches to defining biomechanical abnormalities associated with vascular disease.
On moving to Birmingham in 1989, my interest turned to the cellular adhesive properties of leukocytes and red cells, developing novel flow-based culture and adhesion assays incorporating endothelial cells. We characterised for the first time the dynamic adhesive interactions of flowing malarial parasitised red cells. However, mechanisms by which flowing neutrophils bind to vessel walls came to take precedence, and we were the first to describe the ability of surface-adherent platelets to capture flowing neutrophils.
On moving to Birmingham in 1989, my interest turned to the cellular adhesive properties of leukocytes and red cells, developing novel flow-based culture and adhesion assays incorporating endothelial cells. We characterised for the first time the dynamic adhesive interactions of flowing malarial parasitised red cells. However, mechanisms by which flowing neutrophils bind to vessel walls came to take precedence, and we were the first to describe the ability of surface-adherent platelets to capture flowing neutrophils.
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Biorheologypp.1-18, (2024)
crossref(2023)
Myriam Chimen, Aigli Evryviadou, Clare L Box,Matthew J Harrison,Jon Hazeldine, Lea H Dib,Sahithi J Kuravi,Holly Payne,Joshua M J Price,Dean Kavanagh,Asif J Iqbal,Sian Lax,
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