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职业迁徙
个人简介
Over the past 30 years, I have been engaged in basic and applied biomedical research aimed at characterizing the molecular basis of microbial pathogenesis and host defense with practical applications to diagnosis and control of enteric diseases of animals and human beings. As a board-certified Diplomate of the American College of Veterinary Pathologists and a Professor of Anatomic Veterinary Pathology, I oversee a research program focused on microbial pathogenesis of enteropathogenic Campylobacter and Helicobacter bacterial species in humans and animals, including laboratory mice and non-human primates and polymicrobial infections caused by these pathogens together with the intestinal spirochete Brachyspira pilosicoli. Specifically, I am interested in defining molecular mechanisms of bacterial virulence and host-pathogen interactions in cultured cell and animal models, phenotypic and genotypic bases of microbial diversity, and functional genomics. For the past several years my research efforts have focused on mechanisms of a novel bacterial genotoxin cytolethal distending toxin (CDT)-induced DNA damage response (DDR) within the context of intestinal disease of human and animals. I also collaborate with a wide range of basic research scientists by providing pathology assessment of various laboratory mouse models primarily of intestinal diseases.
研究兴趣
论文共 56 篇作者统计合作学者相似作者
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Santiago Peralta,William Katt,Cheryl Balkman,Scott Butler,Patrick Carney, Amy Todd-Donato, Matthew Drozd,Gerald Duhamel,Nadine Fiani, Jordan Ford,Jennifer Grenier,Jessica Hayward,
Research square (2024)
British journal of pharmacologyno. 20 (2023): 2677-2693
Veterinary pathologyno. 6 (2023): 3009858231197830-897
Frontiers in Veterinary Science (2023): 1281022-1281022
Veterinary and Comparative Oncologyno. 1 (2022): 138-144
VETERINARY AND COMPARATIVE ONCOLOGYno. 1 (2022): 138-144
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