基本信息
浏览量:304
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Current Research and Scholarly Interests
We are interested in the role of chromatin regulation in development and human cancer. Recent studies have show that over 20% of all human cancers have mutations in the subunits of an ATP-dependent chromatin regulatory complex we discovered several years ago. The genes behave as tumor suppressors and sometimes as oncogenes. We hope to understand the fundamental mechanisms used by these complex to prevent cancer.
These same chromatin remodeling complexes are frequently mutated in a variety of human neurologic diseases, reflecting their roles in the development of the nervous system. It appears that these specialized roles in the nervous system are due to the use of unique neural specific assemblies in the developing human and mouse brain. We hope to understand their fundamental mechanism of action through biochemical and genetic approaches in combination with genome-wide analysis and genome sequencing studies.
Finally, we are developing new ways of making conditional alleles of mammalian genes using synthetic ligands that we hope will bring about a new fusion of biochemical and genetic approaches to understanding and controlling fundamental biologic processes. Recently we have developed an effective way of both assaying and modifying chromatin regulation in living cells.
研究兴趣
论文共 503 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Noah Gamble, Alexandra Bradu, Jason A Caldwell,Joshua McKeever,Olubusayo Bolonduro,Ebru Ermis, Caroline Kaiser,YeEun Kim,Benjamin Parks,Sandy Klemm,William J Greenleaf,Gerald R Crabtree,
Nature immunologyno. 6 (2024): 1123-1123
Noah Gamble, Alexandra Bradu, Jason A. Caldwell,Joshua McKeever, Olubusayo Bolonduro,Ebru Ermis, Caroline Kaiser,YeEun Kim,Benjamin Parks,Sandy Klemm,William J. Greenleaf,Gerald R. Crabtree,
Nature Immunologypp.1-13, (2024)
Noah Gamble, Alexandra Bradu, Jason A. Caldwell,Joshua McKeever,Olubusayo Bolonduro,Ebru Ermis, Caroline Kaiser,YeEun Kim,Benjamin Parks,Sandy Klemm,William J. Greenleaf,Gerald R. Crabtree,
NATURE IMMUNOLOGY (2024)
Noah Gamble, Alexandra Bradu, Jason A Caldwell,Joshua McKeever, Olubusayo Bolonduro,Ebru Ermis, Caroline Kaiser,YeEun Kim,Benjamin Parks,Sandy Klemm,William J Greenleaf,Gerald R Crabtree,
Nature immunologyno. 5 (2024): 860-872
bioRxiv (Cold Spring Harbor Laboratory) (2024)
Noah Gamble, Alexandra Bradu, Jason A. Caldwell,Joshua McKeever, Olubusayo Bolonduro,Ebru Ermis, Caroline Kaiser,YeEun Kim,Benjamin Parks,Sandy Klemm,William J. Greenleaf,Gerald R. Crabtree,
Nature Immunology (2024)
Noah Gamble, Alexandra Bradu, Jason A. Caldwell,Joshua McKeever,Olubusayo Bolonduro,Ebru Ermis, Caroline Kaiser,YeEun Kim,Benjamin Parks,Sandy Klemm,William J. Greenleaf,Gerald R. Crabtree,
Nature Immunologypp.1-1, (2024)
Yuan-Hung Lo, Kevin S. Kolahi, Yuhong Du, Chiung-Ying Chang, Andrey Krokhotin, Ajay Nair, Walter D. Sobba, Kasper Karlsson, Sunny J. Jones,Teri A. Longacre, Amanda T. Mah, Bahar Tercan,
crossref(2023)
Sai Gourisankar,Andrey Krokhotin,Wenzhi Ji,Xiaofan Liu,Chiung-Ying Chang, Samuel H. Kim,Zhengnian Li,Wendy Wenderski, Juste M. Simanauskaite,Haopeng Yang,Hannes Vogel,Tinghu Zhang,
Natureno. 7977 (2023): E27-E27
Yuan-Hung Lo, Kevin S. Kolahi, Yuhong Du, Chiung-Ying Chang, Andrey Krokhotin, Ajay Nair, Walter D. Sobba, Kasper Karlsson, Sunny J. Jones, Teri A. Longacre, Amanda T. Mah, Bahar Tercan,
crossref(2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn