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Analytical Chemistry: redox biochemistry, in-vivo measurements with biosensors, development of analytical reagents based on biological recognition, problem-based learning in instrumental analysis.
The measurement of analytes in complex biological media continues to be a challenge. High sensitivity and selectivity are often essential to successful analysis. In addition, in-vivo measurements performed in order to understand time-dependent physiological processes may require good spatial and temporal resolution as well. Successful implementation of such analyses also requires reliable functioning of the analysis system in a matrix often not compatible with the analysis objectives.
Biosensors. A major effort is focused on the development of biosensors suitable for continuous in-vivo monitoring of analytes such as glucose, lactate, glutamate, and oxygen. The objective of this work is to understand the temporal and spatial concentration dependence of these analytes in response to chemical and physical stimuli. These measurements are expected to contribute to the understanding of brain trauma, and other abnormalities, and to the treatment of these conditions. We have been successful in developing a subcutaneously-implantable glucose sensor which is being used to monitor blood glucose in diabetic patients. The effects of the interactions with the surrounding tissue must be considered and this has been a major emphasis in recent years. Sensor design and the effective coupling of the analyte recognition process into the transduction of this event play a key role in defining sensor response characteristics. Attention is focused on the development of sensors with sub-second response times, high selectivity and small size.
The measurement of analytes in complex biological media continues to be a challenge. High sensitivity and selectivity are often essential to successful analysis. In addition, in-vivo measurements performed in order to understand time-dependent physiological processes may require good spatial and temporal resolution as well. Successful implementation of such analyses also requires reliable functioning of the analysis system in a matrix often not compatible with the analysis objectives.
Biosensors. A major effort is focused on the development of biosensors suitable for continuous in-vivo monitoring of analytes such as glucose, lactate, glutamate, and oxygen. The objective of this work is to understand the temporal and spatial concentration dependence of these analytes in response to chemical and physical stimuli. These measurements are expected to contribute to the understanding of brain trauma, and other abnormalities, and to the treatment of these conditions. We have been successful in developing a subcutaneously-implantable glucose sensor which is being used to monitor blood glucose in diabetic patients. The effects of the interactions with the surrounding tissue must be considered and this has been a major emphasis in recent years. Sensor design and the effective coupling of the analyte recognition process into the transduction of this event play a key role in defining sensor response characteristics. Attention is focused on the development of sensors with sub-second response times, high selectivity and small size.
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Archives of Biochemistry and Biophysics (2023): 109612-109612
Lewis G. Halsey,Vincent Careau,Philip N. Ainslie, Heliodoro Aleman-Mateo,Lene F. Andersen,Liam J. Anderson, Leonore Arab,Issad Baddou,Linda Bandini,Kweku Bedu-Addo,Ellen E. Blaak,Stephane Blanc,
Journal of human evolution (2022): 103229-103229
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