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Research in our laboratory is now focused primarily on Alzheimers disease (AD), the most common form of a group of neurodegenerative disorders known collectively as tauopathies. The histopathological hallmark of AD is the presence in brain of extracellular plaques of amyloid-? (A?) peptide fibrils, and intraneuronal neurofibrillary tangles, which are filaments composed of the protein, tau, and are found in all tauopathies. Despite the conspicuous appearance of plaques and tangles, a growing body of evidence points to their building blocks, A? and tau oligomers, as being the toxic molecular species that cause AD. For example, we have found that tau expression is required for several adverse effects of A? oligomers on neurons, including microtubules loss, ectopic re-rentry into the cell cycle, cytotoxicity and impaired mitochondrial activity. The goals of our work are to decipher the metabolic links that connect A? and tau to damage neurons, to define the structures and pathological properties of various types of A? and tau oligomers, and to leverage our basic science findings to develop more effective therapeutic and diagnostic tools for AD.
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论文共 184 篇作者统计合作学者相似作者
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Xuehan Sun,Guillermo Eastman, Yu Shi,Subhi Saibaba,Ana K. Oliveira,John R. Lukens,Andres Norambuena, Joseph A. Thompson, Michael D. Purdy, Kelly Dryden,Evelyn Pardo,James W. Mandell,
ALZHEIMERS & DEMENTIAno. 3 (2024): 1656-1670
Andrés Norambuena, Vijay Kumar Sagar,Zhuoying Wang, Prakash Raut, Ziang Feng,Horst Wallrabe,Evelyn Pardo, Taylor Kim,Shagufta Rehman Alam,Song Hu,Ammasi Periasamy,George S Bloom
bioRxiv : the preprint server for biology (2024)
Alzheimer's & Dementiano. 7 (2023): 2874-2887
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bioRxiv : the preprint server for biology (2023)
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Merci N Best, Yunu Lim,Nina N Ferenc, Nayoung Kim, Lia Min,Dora Bigler Wang,Kamyar Sharifi, Anna E Wasserman,Sloane A McTavish,Karsten H Siller, Marieke K Jones,Paul M Jenkins,
Journal of Alzheimer's disease : JADno. 4 (2023): 1425-1441
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Alzheimer's & Dementiano. S1 (2023)
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