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个人简介
Research Interests:
Dr Uhl has had broad research experience in molecular, pharmacologic and genetic approaches to neurological diseases, pain and addiction.
Current "postGWAS" work in his laboratory follows on his/others identification of genes in which common allelic variants alter neurodegeneration and addiction related phenotypes, initial post GWAS work that replicated some of these phenotpyhes in mouse models and important clues from environmental influences. He is also following up on the novel discovery of substrate specific positive allosteric modulation that his group made in pursuit of these studies.
Dr Uhl's recent intellectual property relating to PTPRD phosphatase inhibitors and substrate selective postivie allosteric modulators provides opportunities for further development of developmental candidate phosphatase inhibtors to first in human use to reduce reward from addictive substances and to reduce obesity. It provides opportunities to move from lead compound flavonol analogs to novel structures for reducing neurofibrillary and other pathologies in Alzheimer's disease (and possibly to prevent development of AD during aging).
Dr Uhl has had broad research experience in molecular, pharmacologic and genetic approaches to neurological diseases, pain and addiction.
Current "postGWAS" work in his laboratory follows on his/others identification of genes in which common allelic variants alter neurodegeneration and addiction related phenotypes, initial post GWAS work that replicated some of these phenotpyhes in mouse models and important clues from environmental influences. He is also following up on the novel discovery of substrate specific positive allosteric modulation that his group made in pursuit of these studies.
Dr Uhl's recent intellectual property relating to PTPRD phosphatase inhibitors and substrate selective postivie allosteric modulators provides opportunities for further development of developmental candidate phosphatase inhibtors to first in human use to reduce reward from addictive substances and to reduce obesity. It provides opportunities to move from lead compound flavonol analogs to novel structures for reducing neurofibrillary and other pathologies in Alzheimer's disease (and possibly to prevent development of AD during aging).
研究兴趣
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Nobue Kitanaka, Kanayo Arai, Kaoko Takehara,F. Scott Hall,Kazuo Tomita,Kento Igarashi,Tomoaki Sato,George R. Uhl,Junichi Kitanaka
BEHAVIOURAL PHARMACOLOGYno. 2/3 (2024): 114-121
ALCOHOL AND ALCOHOLISMno. 2 (2024)
ANNALS OF NEUROLOGY (2023): S152-S153
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Frontiers in Psychiatry (2023): 1031283
Alcohol and Alcoholism (2023)
Research Square (Research Square) (2022)
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