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I have been engaged for many years in the synthesis and photochemical evaluation of photosensitive ‘caged’ compounds as tools for neurophysiological investigations. I have also been involved in the synthesis and application of chemical ligation auxiliaries for their effectiveness in solid-phase peptide synthesis. The scope of the work was not only to develop new technologies but also to improve existing tools for the synthesis of biologically useful proteins and other biomolecules. More recently my research has been focused on the design and synthesis of a variety of small molecules as tools for biomedical research, ranging from modified amino acids, heterocyclic compounds, labelled nucleosides, fluorescent probes for use as enzyme inhibitors or detectors, or as cross linkers in structural studies. Particularly synthesis of inhibitory compounds with potential to be developed as new types of antimalarial drugs or to study the role of Wnt signalling in tissue homeostasis or to study how the Wnt pathway is regulated in intestinal stem cell and cancer.
Research Interests
Papers共 96 篇Author StatisticsCo-AuthorSimilar Experts
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Molecular cellno. 6 (2020): 917-933.e9
BIOPHYSICAL JOURNALno. 3 (2019): 428A-428A
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Author Statistics
#Papers: 95
#Citation: 2228
H-Index: 28
G-Index: 45
Sociability: 5
Diversity: 3
Activity: 4
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