基本信息
浏览量:158
职业迁徙
个人简介
His research interests range from studies of enzyme regulation, bioenergetics and in vivo biochemistry in relation to human disease and in particular heart disease. His early work was concerned with the development of fluorescent probes for the study of structure and function of membranes and enzymes. He soon became interested in the possibility of extending his work to investigate complex biological materials using Nuclear Magnetic Resonance (NMR). In 1974 he published the first paper on the use of phosphorus NMR to study tissue metabolites. The first report of a clinical application of 31P NMR was published in the New England Journal of Medicine in 1981, when his group studied a patient’s muscle metabolism in the rare condition of phosphorylase deficiency (McArdle’s syndrome). These developments led to the setting up of the first clinical magnetic resonance spectroscopy unit in the world and to his appointment to the newly established British Heart Foundation Chair in Molecular Cardiology at Oxford. Since then (and later as Director of the MRC Biochemical and Clinical Magnetic Resonance Unit (1988-1996) he has been involved in the development of this technique for biochemical and Clinical investigations. His research programme in Singapore is aimed at understanding the biological basis of the metabolic syndrome and the mechanisms of interaction between the endocrine system (in particular insulin release and response) with the Central Nervous system. He is leading a new programme on cancer metabolism and the development of hyperpolarized Magnetic Resonance Spectroscopy.
研究兴趣
论文共 74 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Caroline Rae,Richard B Scott,Martin Lee,Judy M Simpson, Nicola Hines, Caroline Paul,Mike Anderson,Annette Karmiloff-Smith,Peter Styles,George K Radda
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn