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Acute pyelonephritis is a common, serious bacterial infection in children, and due to an upsurge of antibiotic resistance, clinical practice is being refocused on preventative measures that limit the use of antimicrobial therapy. Dehydration is linked to renal stress and urinary tract infection (UTI), and increased daily water is a proven effective ancillary treatment for recurrent UTI in premenopausal women. In contrast little attention has been focused on the influence of acid-base state on susceptibility to acute pyelonephritis. In preliminary studies utilizing the C3H-HeOuJ mouse strain that is prone to vesicoureteral reflux (VUR), metabolic acidosis induced by ammonium chloride-loading of mice impaired clearance of UPEC-UTI.
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JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGYno. 1 (2023): 8-13
Journal of the American Society of Nephrologyno. 1 (2023): 8-13
Journal of the American Society of Nephrologypp.ASN.2021101326-ASN.2021101326, (2022)
Physiological Reportsno. 18 (2022): n/a-n/a
Frontiers in clinical diabetes and healthcare (2021)
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