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Bio
The interests of my research team (the Radiobiology & DNA Damage Group) may be summarised as: ‘Mechanisms, Measurement, Enhancement and Consequences of Radiogenic, Oxidative and Drug-Induced Damage to DNA’.
Radiotherapy and chemotherapy used either singly or in combination, are two of the principal modalities for the treatment of cancer. For radiation and many chemotherapeutic drugs, genomic DNA is the primary cellular target for the biological effects of these agents; indeed it is the DNA damage induced which is thought to be responsible for killing the of the cancer cells by these agents.
To better understand, judge and improve treatment efficacy, the purpose of our research is to explore mechanisms to enhance these damaging interactions and to develop methods and biomarkers for the accurate measurement of DNA damage in vitro and in vivo; Importantly, we consider that assessing a biologically significant end-point (DNA damage formation and repair), which takes into account many of the governing chemical, molecular and genetic factors, offers the best chance of assessing, predicting and enhancing a patient's response to treatment. Emphasis is placed on studying clinically relevant doses (avoiding the uncertainty of extrapolation from higher doses) and on translational research themes with anticipated patient benefit.
Since retiring (Dec 2020) and being appointed Professor Emeritus, I have continued to be research-active, most recently investigating the radiogenic mechanisms underpinning the ‘FLASH effect’* [Refs 1 & 2] of high dose rate radiotherapy; * the sparing of normal tissues, whilst not seemingly compromising tumour control.
[1] Br J Radiol 2022; 95: 20211150 https://doi.org/10.1259/bjr.20211150
[2] Int. J. Mol. Sci. 2023, 24, 7195. https://doi.org/10.3390/ijms24087195
Research Interests
Papers共 130 篇Author StatisticsCo-AuthorSimilar Experts
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Mohammad Althubiti,Miran Rada,Jesvin Samuel, Josep M. Escorsa, Hishyar Najeeb,Koon-Guan Lee,Kong-Peng Lam,George D.D. Jones,Nickolai A. Barlev,Salvador Macip
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International journal of molecular sciencesno. 8 (2023): 7195-7195
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Author Statistics
#Papers: 120
#Citation: 3810
H-Index: 37
G-Index: 58
Sociability: 6
Diversity: 0
Activity: 1
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