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Our current research interests are in the area of antibiotic discovery for "neglected" diseases. Tuberculosis is a global human health problem of staggering proportions, causing 1.8 million deaths in 2016. Current TB drugs require up to nine months of treatment and poor compliance promotes the emergence of drug-resistant strains. We are using both structure-based and high-throughput screening approaches to discover improved RNAP inhibitors in collaboration with the VMCC here at U-M, the Franzblau lab at UIC and the Murakami lab at Penn State. Shigella flexneri is a human enteropathogen that infects ca. 165 million people and claims more than 1 million lives per year worldwide. Targeting Shigella virulence pathways is attractive because such drugs would be expected to exhibit less emergence of drug resistance and have no effect on normal colonic microbiota. We are using high-throughput screening to find molecules that block Shigella virulence without bacteriacidal activity. Our current focus is the transcription factor VirF, which initiates expression of the key Shigella virulence genes.
Research Interests
Papers共 76 篇Author StatisticsCo-AuthorSimilar Experts
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Marija Miljkovic,Sonia Lozano,Isabel Castellote,Cristina de Cozar,Ana I. Villegas-Moreno,Pablo Gamallo, Dolores Jimenez-Alfaro Martinez,Elena Fernandez-Alvaro,Lluis Ballell,George A. Garcia
mSphereno. 5 (2023)
Journal of bacteriologyno. 4 (2023)
BIOENGINEERING & TRANSLATIONAL MEDICINEno. 2 (2022): n/a-n/a
Scientific reportsno. 1 (2020): 21309-21309
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2019)
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#Papers: 74
#Citation: 1883
H-Index: 27
G-Index: 41
Sociability: 5
Diversity: 3
Activity: 1
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