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Decades of research in the area of metabolic adjustments to exercise led to articulation of two working hypotheses: the "Lactate Shuttle," and the "Crossover Concept." Research on the Lactate Shuttle was to elucidate the pathways and controls of lactate formation and removal before, during and after exercise. That work involved studies on humans and animals, indirect calorimetry, isotope tracer technology, classic arterial-venous difference measurements, and muscle biopsies. As well, we sought to determine the factors that determine the expression of lactate transport proteins and their cellular domains. In recent years, generality of the Lactate Shuttle mechanism has impacted diverse fields such as neuro- and cancer cell biology. Most recently, from our collaboration with colleagues in Neurosurgery at UCLA we have made important discoveries on the fueling of body and brain following Traumatic Brain Injury (TBI). Hence, from a basic understanding of energy substrate utilization during physical activity we are now in position to improve standard of care, increase survival, and improve outcomes for people suffering brain and other forms of trauma. By virtue of significant research collaborations with other laboratories in the University of California and elsewhere, students, post-doctoral fellows, research staff, and visiting scientists the opportunity to work in important and exciting areas of science all with goal of improving the human condition.
Research Interests
Papers共 516 篇Author StatisticsCo-AuthorSimilar Experts
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Physiologyno. S1 (2024)
Physiologyno. S1 (2024)
American journal of physiology. Endocrinology and metabolism (2024)
Physiologyno. S1 (2024)
The Journal of physiologyno. 14 (2024): 3233-3235
biorxiv(2023)
MEDICINE & SCIENCE IN SPORTS & EXERCISEno. 9 (2023): 548-549
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