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I conduct both basic and translational research on cyclin-dependent kinase inhibitors. A major goal is to define the role of one of these inhibitors, p16ink4a in the cellular response to DNA damage. In addition, I am directing both preclinical and clinical studies of several potent pharmacologic cyclin-dependent kinase inhibitors. Several phase I trials are underway investigating these agents in patients with advanced solid tumors. The work involves the assessment of these drugs alone, as well as in combination with standard chemotherapy agents and signal transduction inhibitors.
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Claire F. Friedman, Anishka D'Souza, Diana Bello Roufai,Anna Tinker, Maria de Miguel, Valentina Gambardella,Jonathan Goldman,Sherene Loi,Michelle E. Melisko,Ana Oaknin,Iben Spanggaard,Geoffrey I. Shapiro,
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CANCER RESEARCHno. 23 (2023): 3956-3973
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Nami Yamashita,Yoshihiro Morimoto,Atsushi Fushimi,Rehan Ahmad,Atrayee Bhattacharya,Tatsuaki Daimon,Naoki Haratake, Yuka Inoue,Satoshi Ishikawa,Masaaki Yamamoto,Tsuyoshi Hata, Sayuri Akiyoshi,
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