基本信息
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Bio
Research in Dr. Abbott’s lab is focused on elucidating the molecular basis for ion channel and transporter physiology and pathophysiology. One of the main directions of the lab has been to define the roles of the KCNE and KCNQ gene families of potassium channel subunits, using a combination of techniques including mouse and human genetics, electrophysiology, pharmacology, transcriptomics, and state-of-the-art imaging modalities. This includes research stemming from our unexpected discovery that the neurotransmitter GABA and related molecules can bind directly to certain voltage-gated potassium channels to activate them. Another major focus is the discovery of the molecular mechanisms underlying the beneficial actions of traditional herbal and other botanical medicines. Other interests include discovery of novel ion channel subunits and small molecules to modulate ion channel function, ion channel-transporter interactions, and investigation of ion channel trafficking. Abnormal functioning of ion channels can cause disorders including cardiac arrhythmia, epilepsy, myotonia, ataxia, periodic paralysis, hypothyroidism and cancer. We are employing a multidisciplinary approach aimed at understanding the molecular etiologies of, and ultimately developing therapies for, a wide spectrum of “channelopathies” - human diseases arising from ion channel dysfunction.
Research Interests
Papers共 212 篇Author StatisticsCo-AuthorSimilar Experts
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Rían W Manville, Samantha D Block, Claire L Illeck, Jessica Kottmeier,Richard Sidlow,Geoffrey W Abbott
Frontiers in cellular neuroscience (2024): 1438101-1438101
Brain (2024)
Elizabeth A Forrester, Miguel Benítez-Angeles, Kaitlyn E Redford,Tamara Rosenbaum,Geoffrey W Abbott, Vincenzo Barrese,Kim Dora, Anthony P Albert, Johs Dannesboe, Isabelle Salles-Crawley,Thomas A Jepps,Iain A Greenwood
Cardiovascular research (2024)
FASEB JOURNALno. 7 (2023)
BRITISH JOURNAL OF PHARMACOLOGYno. 4 (2023): 560-561
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American journal of physiology. Regulatory, integrative and comparative physiologyno. 6 (2023): R747-R760
Rian W. Manville,Samuel N. N. Baldwin, Emil Ornberg Eriksen,Thomas A. A. Jepps,Geoffrey W. W. Abbott
The FASEB journalno. 9 (2023)
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Author Statistics
#Papers: 208
#Citation: 9257
H-Index: 40
G-Index: 93
Sociability: 6
Diversity: 4
Activity: 78
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