基本信息
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Career Trajectory
Bio
Dr. Genhong Cheng's laboratory studies molecular events involved in host defense against pathogen infections. Cheng and his colleagues have recently identified several gene programs specific for antiviral or antibacterial responses. In some cases, the researchers found that host responses to bacterial infection and viral infection may even be opposite. For example, type I interferon, an essential antiviral cytokine, might play a harmful role in host defense against certain bacterial infection. Cheng's laboratory also is interested in understanding the mechanisms of chemoresistance and developing novel strategies to improve cancer treatment. They have found that many chemotherapy agents commonly used clinically that are supposed to kill tumor cells can actually activate alternative cell survival pathways to protect tumor cells. This phenomenon may represent a potential mechanism of chemoresistance. Furthermore, Cheng and his colleagues found that blocking the NF- B-dependent up-regulation of Bcl-x and Bfl-1 genes can greatly reduce chemoresistance and sensitize chemotherapy-mediated apoptosis. Cheng's laboratory is currently evaluating the possibility of using the combination of NF- B inhibitors and chemotherapy agents for cancer therapy.
Research Interests
Papers共 348 篇Author StatisticsCo-AuthorSimilar Experts
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期刊级别
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Cell & Bioscienceno. 1 (2024): 1-17
Frontiers in Immunology (2024)
Nina Sun,Qiaomei Cai,Yurui Zhang,Rong-Rong Zhang, Jingmei Jiang,Heng Yang,Cheng-Feng Qin,Genhong Cheng
SCIENCE SIGNALINGno. 818 (2024)
Lili Li,Meiling Gao,Jie Li,Xuping Xie, Hui Zhao, Yanan Wang, Xin Xu,Shulong Zu,Chunfeng Chen,Dingyi Wan,Jing Duan,Jingfeng Wang,
Chau Ngo, William Fried,Saba Aliyari, Joshua Feng,Chao Qin,Shilei Zhang,Hanjing Yang, Jean Shanaa,Pinghui Feng,Genhong Cheng,Xiaojiang S. Chen,Chao Zhang
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Author Statistics
#Papers: 351
#Citation: 43825
H-Index: 98
G-Index: 207
Sociability: 7
Diversity: 4
Activity: 132
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