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Research in Dr. Cheng's laboratory is aimed at the process of innate and adaptive immune responses in host defense against bacterial and viral infections as well as tumor challenges. Upon recognizing pathogen infections, host cellular receptors such as Toll-like and Nod family receptors can trigger a series of signal transduction and gene expression networks (gene programs) to initiate innate immune responses. These innate immune responses can directly control the replication or spread of bacteria and viruses through induction of phagocytosis or antimicrobial products. In addition, innate immune response can also instruct the activation of adaptive immune response through induction of antigen presentation and co-stimulatory molecules. Defects in any steps in the process of innate and adaptive immune responses can increase susceptible of hosts to pathogen infections, whereas over-reactive immune responses can also lead to many inflammatory diseases and metabolic syndromes. We hope to understand the similarity and difference in host immune responses to different types of bacterial and viral infections, the balance between immune and inflammatory responses, the crosstalk between host immune and metabolic systems. Our goal is to develop novel strategies to enhance our immune system against pathogen infections and tumor challenges while to prevent or inhibit inflammatory and metabolic diseases.
Research in Dr. Cheng's laboratory is aimed at the process of innate and adaptive immune responses in host defense against bacterial and viral infections as well as tumor challenges. Upon recognizing pathogen infections, host cellular receptors such as Toll-like and Nod family receptors can trigger a series of signal transduction and gene expression networks (gene programs) to initiate innate immune responses. These innate immune responses can directly control the replication or spread of bacteria and viruses through induction of phagocytosis or antimicrobial products. In addition, innate immune response can also instruct the activation of adaptive immune response through induction of antigen presentation and co-stimulatory molecules. Defects in any steps in the process of innate and adaptive immune responses can increase susceptible of hosts to pathogen infections, whereas over-reactive immune responses can also lead to many inflammatory diseases and metabolic syndromes. We hope to understand the similarity and difference in host immune responses to different types of bacterial and viral infections, the balance between immune and inflammatory responses, the crosstalk between host immune and metabolic systems. Our goal is to develop novel strategies to enhance our immune system against pathogen infections and tumor challenges while to prevent or inhibit inflammatory and metabolic diseases.
研究兴趣
论文共 93 篇作者统计合作学者相似作者
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Cell & Bioscienceno. 1 (2024): 1-17
Nina Sun,Qiaomei Cai,Yurui Zhang,Rong-Rong Zhang, Jingmei Jiang,Heng Yang,Cheng-Feng Qin,Genhong Cheng
SCIENCE SIGNALINGno. 818 (2024): eadf8016-eadf8016
Chau Ngo, William Fried,Saba Aliyari, Joshua Feng,Chao Qin,Shilei Zhang,Hanjing Yang, Jean Shanaa,Pinghui Feng,Genhong Cheng,Xiaojiang S Chen,Chao Zhang
Manuel F. Lopez-Aranda,Gayle M. Boxx,Miranda Phan, Karen Bach,Rochelle Mandanas, Isaiah Herrera,Sunrae Taloma,Chirag Thadani,Odilia Lu, Raymond Bui,Shuhan Liu,Nan Li,
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCEno. 3 (2023): 451-459
Cellular & Molecular Immunologyno. 6 (2022): 754-754
Liping Yang,Shengchuan Chen, Qun Zhao,Chaohu Pan,Linan Peng,Yu Han, Lili Li,Jiayin Ruan, Jingyan Xia,Heng Yang, Feng Xu,Genhong Cheng
Cell & bioscienceno. 1 (2021): 116-116
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