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Trained in biology and pathology, Gary Stein has a longstanding dedication to translating mechanistic understanding of cancer biology into clinically relevant investigation with the potential for advancing cancer prevention, early detection and therapy. Transdisciplinary team research has always been a key approach for Gary Stein – it has been the guiding strategy for his own research group and he actively advocates collaboration in his role as Chair of the University of Vermont Department of Biochemistry and Director of the University of Vermont Cancer Center.
Research Interests
Genetic and Epigenetic Control in Cancer Biology and Pathology
The central theme of Gary Stein’s research is to discover mechanisms that control proliferation and differentiation, with an emphasis on compromised genetic and epigenetic regulation linked with cancer. The priority of his research group is discovery of mechanisms, molecular signatures and biomarkers, including those driven by intra- and inter-chromosomal interactions and noncoding RNAs. These initiatives are directed toward advancing capabilities for prevention, early detection, treatment and survivorship of leukemia, breast and prostate cancer, as well as mechanistic and clinical understanding of solid tumor metastasis to bone. The laboratory has consistently been at the forefront of characterizing genetic and epigenetic regulation that mediates cell cycle control in lineage-committed cells, cancer stem cells, and pluripotent and induced pluripotent stem cells with an abbreviated cell cycle. The Stein lab has made pivotal contributions to understanding the transcriptome by defining mechanisms that govern combinatorial organization and assembly of regulatory machinery in nuclear microenvironments, higher-order genomic organization and epigenetic control of cell fate and lineage commitment in biological control and cancer. His recent discoveries of mitotic bookmarking and mitosis-specific bivalent histone modifications in pluripotent stem cells that are recapitulated in early stage breast and prostate cancer cells establish “oncofetal epigenetic control” as a novel dimension to tumorigenesis.
Trained in biology and pathology, Gary Stein has a longstanding dedication to translating mechanistic understanding of cancer biology into clinically relevant investigation with the potential for advancing cancer prevention, early detection and therapy. Transdisciplinary team research has always been a key approach for Gary Stein – it has been the guiding strategy for his own research group and he actively advocates collaboration in his role as Chair of the University of Vermont Department of Biochemistry and Director of the University of Vermont Cancer Center.
Research Interests
Genetic and Epigenetic Control in Cancer Biology and Pathology
The central theme of Gary Stein’s research is to discover mechanisms that control proliferation and differentiation, with an emphasis on compromised genetic and epigenetic regulation linked with cancer. The priority of his research group is discovery of mechanisms, molecular signatures and biomarkers, including those driven by intra- and inter-chromosomal interactions and noncoding RNAs. These initiatives are directed toward advancing capabilities for prevention, early detection, treatment and survivorship of leukemia, breast and prostate cancer, as well as mechanistic and clinical understanding of solid tumor metastasis to bone. The laboratory has consistently been at the forefront of characterizing genetic and epigenetic regulation that mediates cell cycle control in lineage-committed cells, cancer stem cells, and pluripotent and induced pluripotent stem cells with an abbreviated cell cycle. The Stein lab has made pivotal contributions to understanding the transcriptome by defining mechanisms that govern combinatorial organization and assembly of regulatory machinery in nuclear microenvironments, higher-order genomic organization and epigenetic control of cell fate and lineage commitment in biological control and cancer. His recent discoveries of mitotic bookmarking and mitosis-specific bivalent histone modifications in pluripotent stem cells that are recapitulated in early stage breast and prostate cancer cells establish “oncofetal epigenetic control” as a novel dimension to tumorigenesis.
研究兴趣
论文共 804 篇作者统计合作学者相似作者
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Yasaman Daneshian,Eric Lewallen, Amr Badreldin,Allan Dietz,Gary Stein,Simon Cool,Hyun-Mo Ryoo,Young Dan Cho,Andre van Wijnen
Critical Reviews in Eukaryotic Gene Expression (2024)
Kirsten M. Tracy, Shannon Prior, Willem T. Trowbridge,Joseph R. Boyd,Prachi N. Ghule,Seth Frietze,Janet L. Stein,Gary S. Stein,Jane B. Lian
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSIONno. 2 (2024): 61-72
Gary E. Carver,Sarah A. Locknar,Prachi N. Ghule, Christopher J. Pung,Donald L. Weaver,Janet L. Stein,Gary S. Stein
Critical reviews in eukaryotic gene expressionno. 1 (2024): 69-74
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Critical reviews in eukaryotic gene expressionno. 4 (2024): 69-102
crossref(2023)
Ricardo Medina,Sayyed K. Zaidi,Chang-Gong Liu,Janet L. Stein, Andre J. vanWijnen,Carlo M. Croce,Gary S. Stein
crossref(2023)
Jitesh Pratap, Karen M. Imbalzano, Jean M. Underwood,Nathalie Cohet,Karthiga Gokul,Jacqueline Akech,Andre J. van Wijnen,Janet L. Stein,Anthony N. Imbalzano,Jeffrey A. Nickerson,Jane B. Lian,Gary S. Stein
crossref(2023)
crossref(2023)
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