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Bio
Dr. Ehrlich and his lab are interested in how chronic bacterial pathogens persist in the face of antimicrobial therapy, and the innate and adaptive host responses. To understand this complex phenomenon, Dr. Ehrlich promulgated the rubric of “bacterial plurality,” which embodies the concept that chronic pathogens display enormous heterogeneity at many levels including: phenotypic, metabolic and genotypic. The reasoning behind the development of this theoretical construct was to provide a paradigm that more accurately models chronic pathogenic processes enabling the development of rational therapies for these diseases that are recalcitrant to current medical management. It is our belief that the extant paradigms of bacterial pathogenesis passed down to us from Robert Koch and developed for acute epidemic infections, although powerful and useful for clonal planktonic infections, acted for decades as blinders toward our understanding of chronic infections.
Research Interests
Papers共 390 篇Author StatisticsCo-AuthorSimilar Experts
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Research square (2024)
Johanna Nokso-Koivisto,Garth D. Ehrlich,Frida Enoksson,Kensei Komatsu,Kevin Mason,Asa Melhus,Janak A. Patel, Shiyan Vijayasekaran,Allen Ryan
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY (2024): 111798-111798
Infection and immunityno. 3 (2024): e0052923-e0052923
Frontiers in cellular and infection microbiology (2023): 1123228-1123228
Microorganismsno. 6 (2023): 1515-1515
Genetic testing and molecular biomarkersno. 12 (2023): 361-361
Alzheimer's & Dementiano. 11 (2023): 5209-5231
Alzheimer's & dementia : the journal of the Alzheimer's Associationno. 11 (2023): 5209-5231
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Author Statistics
#Papers: 392
#Citation: 23197
H-Index: 75
G-Index: 144
Sociability: 7
Diversity: 1
Activity: 2
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