基本信息
浏览量:342
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Research in the Gao Lab primarily involves the discovery, development and use of adeno-associated virus vectors for gene therapy of genetic diseases and the study of miRNA functions in mammals. The lab works on isolation, characterization and vectorology of novel AAV vectors from primate tissues, molecular mechanisms of AAV evolution and diversity, and molecular interactions between endogenous AAV, AAV vector, host genomes and innate RNAi defense pathways. We also develop novel strategies for rAAV gene therapy of an inherited neurodegenerative disease, Canavan Disease, using novel AAVs that can cross the blood-brain-barrier for efficient CNS gene delivery and endogenous miRNA-mediated posttranscriptional de-targeting. Another area of research interest in the lab is to explore AAV vectors for delivery of denovo synthesized biological miRNA antagonists or over expression of microRNAs to elucidate micro RNA functions in adult mammals.
研究兴趣
论文共 267 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Chujiao Lin,Yeon-Suk Yang,Hong Ma, Zhihao Chen, Dong Chen,Aijaz Ahmad John,Jun Xie,Guangping Gao,Jae-Hyuck Shim
Molecular Therapy (2024)
Qing Xie,Xiupeng Chen, Hong Ma, Yunxiang Zhu, Yijie Ma,Leila Jalinous, Gerald F Cox, Fiona Weaver, Jun Yang,Zachary Kennedy,Alisha Gruntman,Ailing Du,
Hao Liu,Yue Zhang,Mitchell Yip,Lingzhi Ren,Jialing Liang,Xiupeng Chen, Nan Liu,Ailing Du,Jiaming Wang,Hao Chang, Hyejin Oh,Chen Zhou,
Molecular Therapy - Methods & Clinical Developmentno. 2 (2024): 101230-101230
Neurotherapeuticsno. 4 (2024): e00391-e00391
Shun-Qing Liang,Andrew W Navia, Michelle Ramseier, Xuntao Zhou,Michele Martinez,Charles Lee,Chen Zhou, Joae Wu,Jun Xie,Qin Su,Dan Wang,Terence R Flotte,
Human gene therapy (2024)
SIGNAL TRANSDUCTION AND TARGETED THERAPYno. 1 (2024): 78-78
Human gene therapyno. 9-10 (2024): 317-328
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn