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个人简介
Dr. Zheng’s research is focused on the development of novel technology platforms for molecular imaging, photodynamic therapy (PDT) and nanomedicine.
The main interest of the Zheng group is to develop two new drug platforms to combat cancer: 1) light-activated intelligent molecules and 2) nature-inspired theranostic nanomedicine. Our lab introduced the concept of activatable photodynamic therapy agents which enable these photoactive drugs to be silenced in normal cells but toxic to cancer cells expressing specific signatures. This can great mitigate the collateral damage that often limits in cancer therapy. By mimicking how lipoproteins assemble and function, we created new drug delivery vehicles that imitate the structure and behavior of natures own nanoparticles. Such biomimetic design has enabled direct cytosolic transport of cancer therapeutics thus bypassing endosomal trafficking that is detrimental to drug efficacy. Our lab also discovered an unprecedented class of phototransducing lipid nanoparticles that expand the role of conventional organic nanoparticles beyond traditional drug delivery vehicles to powerful and versatile biophotonic tools.
The main interest of the Zheng group is to develop two new drug platforms to combat cancer: 1) light-activated intelligent molecules and 2) nature-inspired theranostic nanomedicine. Our lab introduced the concept of activatable photodynamic therapy agents which enable these photoactive drugs to be silenced in normal cells but toxic to cancer cells expressing specific signatures. This can great mitigate the collateral damage that often limits in cancer therapy. By mimicking how lipoproteins assemble and function, we created new drug delivery vehicles that imitate the structure and behavior of natures own nanoparticles. Such biomimetic design has enabled direct cytosolic transport of cancer therapeutics thus bypassing endosomal trafficking that is detrimental to drug efficacy. Our lab also discovered an unprecedented class of phototransducing lipid nanoparticles that expand the role of conventional organic nanoparticles beyond traditional drug delivery vehicles to powerful and versatile biophotonic tools.
研究兴趣
论文共 421 篇作者统计合作学者相似作者
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Axel Sahovaler,Michael S Valic,Jason L Townson,Harley H L Chan,Mark Zheng,Sharon Tzelnick, Tiziana Mondello, Alon Pener-Tessler,Donovan Eu, Abdullah El-Sayes,Lili Ding,Juan Chen,
Cancer research communications (2024)
Axel Sahovaler,Michael S. Valic,Jason L. Townson,Harley H.L. Chan,Mark Zheng,Sharon Tzelnick, Tiziana Mondello, Alon Pener-Tessler,Donovan Eu, Abdullah El-Sayes,Lili Ding,Juan Chen,
crossref(2024)
Axel Sahovaler,Michael S. Valic,Jason L. Townson,Harley H.L. Chan,Mark Zheng,Sharon Tzelnick, Tiziana Mondello, Alon Pener-Tessler,Donovan Eu, Abdullah El-Sayes,Lili Ding,Juan Chen,
crossref(2024)
Yaoxing Chen,Yuxiao Ma, Kexin Shi, Huan Chen,Xiao Han, Chenxuan Wei, Yingqi Lyu,Yukun Huang,Renhe Yu,Yun Song,Qingxiang Song,Jiyao Jiang,
Advanced materials (Deerfield Beach, Fla.)no. 15 (2024): e2307454-e2307454
Axel Sahovaler,Michael S. Valic,Jason L. Townson,Harley H.L. Chan,Mark Zheng,Sharon Tzelnick, Tiziana Mondello, Alon Pener-Tessler,Donovan Eu, Abdullah El-Sayes,Lili Ding,Juan Chen,
crossref(2024)
ADVANCED SCIENCEno. 4 (2024): e2304453-e2304453
Nature Nanotechnologyno. 3 (2024): 376-386
Axel Sahovaler,Michael S. Valic,Jason L. Townson,Harley H.L. Chan,Mark Zheng,Sharon Tzelnick, Tiziana Mondello, Alon Pener-Tessler,Donovan Eu, Abdullah El-Sayes,Lili Ding,Juan Chen,
crossref(2024)
Axel Sahovaler,Michael S. Valic,Jason L. Townson,Harley H.L. Chan,Mark Zheng,Sharon Tzelnick, Tiziana Mondello, Alon Pener-Tessler,Donovan Eu, Abdullah El-Sayes,Lili Ding,Juan Chen,
crossref(2024)
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2024): 103949-103949
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