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Our research interests focus broadly on the role for chromatin modification and epigenetic mechanism in gene regulation, development and disease, notably cancer. Our recent works in this broad field have shown that dysregulation of enzymes and effectors involved in histone and DNA methylation causally leads to gene expression deregulation and cancer development. We favor a general view that human disease including cancer often arises from dysregulation of an “epigenetic language” embedded in the genome, when it is mis-written, mis-erased or mis-interpreted. Currently, our laboratory employs cutting-edge techniques, which include CRISPR/cas9-based genomic editing, deep sequencing and small-molecule epigenetic inhibitors, to address issues relating to fundamentals of epigenetics and cancer therapeutics. Multiple on-going projects are (1) biochemical characterization of novel factors/complexes that read chromatin modification; (2) CRISPR/dCas9-based editing of epigenomic modifications for understanding their roles in gene function; (3) knockout and knock-in mouse models with deficiency in chromatin regulators in context of development and tumorigenesis; (4) epigenomic and transcriptome analyses (ChIP-Seq and RNA-Seq) of normal versus cancer cells to delineate pathways essential for tumor growth.
Research Interests
Papers共 120 篇Author StatisticsCo-AuthorSimilar Experts
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I-Hsin Cheng,Wen-Chieh Pi, Chung-Hao Hsu,Yiran Guo, Jun-Lin Lai,Gang G Wang,Bon-Chu Chung,Robert G Roeder,Wei-Yi Chen
Cell death discoveryno. 1 (2024): 244-244
Ronan P Hanley,David Y Nie, John R Tabor, Fengling Li,Amin Sobh,Chenxi Xu,Natalie K Barker,David Dilworth,Taraneh Hajian,Elisa Gibson,Magdalena M Szewczyk,Peter J Brown,
Journal of the American Chemical Societyno. 14 (2023): 8176-8188
Natureno. 7987 (2023): 633-642
ONCOGENEno. 13 (2023): 994-1009
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Author Statistics
#Papers: 125
#Citation: 8536
H-Index: 39
G-Index: 92
Sociability: 6
Diversity: 0
Activity: 2
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