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Gaby's research group was the first to show that PASK gene expression is lower in pancreatic islets from type 2 diabetic patients vs non-diabetic individuals (7), indicating that loss of PASK may be related to the loss of islet function seen in type 2 diabetes. Gaby's research group has also shown that PASK is a regulator of insulin gene expression in pancreatic β cells (6), and may be involved in the regulation of glucagon release from pancreatic α cells (7). The group also showed that PASK may have a role in the glucose sensing pathway in α cells, and may regulate glucagon secretion through its effects on insulin production in pancreatic β cells (1; 7). The group also showed that the expression of the gene encoding for the AMPK α-2 catalytic subunit is increased in α cells in which Pask gene expression has been silenced (7). AMPK has been implicated in the regulation of glucagon release (8), raising the possibility that PASK may regulate glucose sensing in the α cell through the modulation of AMPKα-2 content. The group's studies on embryonic pancreatic explants also indicate that PASK may have a role in pancreatic development (7).
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Papers共 109 篇Author StatisticsCo-AuthorSimilar Experts
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DIABETES OBESITY & METABOLISMno. 3 (2024): 989-996
Frontiers in Endocrinology (2023): 1275835-1275835
Diabetes, obesity & metabolismno. 3 (2023): 989-996
bioRxiv (Cold Spring Harbor Laboratory)pp.1-25, (2020)
DIABETOLOGIAno. 7 (2020): 1368-1381
Endocrine Abstracts (2019)
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