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Bio
He working on elucidating the mechanism of action of anti-neoplastic drugs under the supervision of Prof. Giulio Superti-Furga at CeMM. He specialized in proteomics as well as chemical genetic approaches to identifying drug resistance mechanisms and on mechanistically elucidating synergistic drug combinations. He continued his training in chemical biology. There, he innovated a generalizable pharmacological solution to in vivo target protein degradation and applied this strategy to the study of leukemic gene regulation. His lab develops and applies methods for target protein degradation with the ultimate goal of understanding and disrupting oncogenic transcriptional circuits. To that end, the Winter laboratory combines phenotypic drug screens, chemical genetics and drug-target identification approaches with holistic measurements of global gene activity and genome structure. The ultimate goal of the research conducted in the Winter laboratory is to connect basic research in gene regulation and the ubiquitin-proteasome system with functional genomics and chemical probe development to develop novel and personalized therapeutic paradigms.
Research Interests
Papers共 112 篇Author StatisticsCo-AuthorSimilar Experts
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Barbara M. G. Barbosa, Aikaterini Sfyaki, Sergi Rafael, Ferran Jose-Duran,Joan Pous,Carolina Sanchez-Zarzalejo,Carles Perez-Lopez,Mar Vilanova,Marko Cigler,Marina Gay,Marta Vilaseca,Georg E. Winter,
ANGEWANDTE CHEMIE-INTERNATIONAL EDITIONno. 12 (2024): e202316730-e202316730
NATURE CHEMICAL BIOLOGYpp.1-10, (2024)
Marco Jochem,Anna Schrempf, Lina-Marie Wagner, Jose Cisneros, Amanda Ng,Georg E. Winter,Jeroen Krijgsveld
biorxiv(2024)
Fabian Offensperger,Gary Tin,Miquel Duran-Frigola,Elisa Hahn, Sarah Dobner,Christopher W Am Ende,Joseph W Strohbach,Andrea Rukavina, Vincenth Brennsteiner,Kevin Ogilvie,Nara Marella, Katharina Kladnik,
Nianzhe He,Laura Depta,Cecilia Rossetti,Lucie Caramelle,Marko Cigler,Hogan P Bryce-Rogers, Marine Michon, Oliver Rafn Dan,Joseph Hoock,Julien Barbier,Daniel Gillet,Alison Forrester,
Nature chemical biologypp.1-12, (2024)
Chrysanthi Kagiou,Jose A Cisneros, Jakob Farnung,Joanna Liwocha,Fabian Offensperger, Kevin Dong, Ka Yang,Gary Tin, Christina S Horstmann,Matthias Hinterndorfer,Joao A Paulo,Natalie S Scholes,
Nature communicationsno. 1 (2024): 5409-5409
Bioorganic & Medicinal Chemistry Letters (2024): 129779-129779
Nature Chemical Biologyno. 1 (2024): 13-14
Zuzanna Kozicka, Dakota J. Suchyta, Vivian Focht,Georg Kempf,Georg Petzold,Marius Jentzsch,Charles Zou,Cristina Di Genua,Katherine A. Donovan,Seemon Coomar,Marko Cigler,Cristina Mayor-Ruiz,
Natalie S. Scholes, Martino Bertoni, Arnau Comajuncosa-Creus, Katharina Kladnik,Fabian Frommelt,Matthias Hinterndorfer, Hlib Razumkov,Polina Prokofeva, Martin P. Schwalm,Hana Imrichova, Eleonora Barone, Caroline Schätz,
biorxiv(2024)
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