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Research interest
We analyse data from a number of genomic technologies, especially RNA sequencing (RNA-seq), but also DNA sequencing, gene expression microarrays, protein arrays, mass spectrometry and high-throughput PCR arrays. One of our key interests is the identification of genes, transcripts or molecular pathways that are differentially expressed between experimental conditions. We also analyse ChIP sequencing experiments to detect changes in the DNA epigenetic marks and DNA structure.
We develop high performance algorithms to map short sequence reads to a reference genome. We use mathematical techniques such a linear modelling and empirical Bayes to borrow strength between genes and between experimental units, providing robust statistical conclusions even when the number of experimental units is relatively small.
We collaborate closely with institute scientists on a range of human diseases including breast cancer, lung cancer, multiple sclerosis and various immunological disorders.
研究兴趣
论文共 453 篇作者统计合作学者相似作者
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Rachel Joyce,Rosa Pascual, Luuk Heitink,Bianca D. Capaldo,François Vaillant,Michael Christie,Minhsuang Tsai,Elliot Surgenor, Casey J. A. Anttila, Pradeep Rajasekhar,Felicity C. Jackling,Marie Trussart,
Nature Cell Biologyno. 1 (2024): 138-152
Maria I. Bergamasco, Nishika Ranathunga, Waruni Abeysekera,Connie S N Li-Wai-Suen, Alexandra L. Garnham, Simon N. Willis,Helen M. McRae, Yuqing Yang, Angela D’Amico,Ladina Di Rago, Stephen Wilcox,Stephen L. Nutt,
Stem Cell Reportsno. 4 (2024): 469-485
Benjamin John Hunter,Mengbo Li,Benjamin L Parker,Yen Chin Koay,Dylan Harney, Evangeline Pearson,Jacob Yiming Cao, Gavin Chen, Oneka Guneratne,Gordon K Smyth,Mark Larance, John F O'Sullivan,
crossref(2024)
biorxiv(2024)
Sophia Y. Y. Mah,Hannah K. Vanyai, Connie S. N. Li-Wai-Suen, Alexandra L. Garnham, Jessica Wynn, Maria I. Bergamasco, Shezlie Malelang,Stephen Wilcox,Christine Biben,Gordon K. Smyth,Tim Thomas,Anne K. Voss
DEVELOPMENTno. 5 (2024)
Julie Tellier, Ilariya Tarasova,Junli Nie, Christopher S. Smillie,Pasquale L. Fedele,Wang H. J. Cao,Joanna R. Groom,Gabrielle T. Belz,Deepta Bhattacharya,Gordon K. Smyth,Stephen L. Nutt
Nature Immunologyno. 2 (2024): 330-342
Maria I. Bergamasco,Hannah K. Vanyai,Alexandra L. Garnham,Niall D. Geoghegan, Adam P. Vogel,Samantha Eccles,Kelly L. Rogers,Gordon K. Smyth,Marnie E. Blewitt,Anthony J. Hannan,Tim Thomas,Anne K. Voss
Genome research (2024)
Mitra Ashayeripanah,Javier Vega-Ramos,Daniel Fernandez-Ruiz, Shirin Valikhani,Aaron T. L. Lun,Jason T. White,Louise J. Young, Atefeh Yaftiyan,Yifan Zhan,Linda Wakim,Irina Caminschi,Mireille H. Lahoud,
Pedro L. Baldoni,Yunshun Chen, Soroor Hediyeh-zadeh,Yang Liao,Xueyi Dong,Matthew E. Ritchie,Wei Shi,Gordon K. Smyth
NUCLEIC ACIDS RESEARCHno. 3 (2024): e13-e13
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