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I am primarily interested in cellular changes as a result of neurodegenerative disease and damage states. The major tools I use are antibody reagents and assays made using these reagents, and one recent focus has been on the validation of phosphorylated axonal forms of NF-H (pNF-H) as a CSF and blood biomarker of axonal loss in a variety of damage and disease states. A second project looks at the potential use of ubiquitin C-terminal hydrolase 1 (UCHL1) as a potential blood and CSF biomarker of cortical injury and degeneration. We have also developed a novel and high quality assay for alpha-synuclein, a Parkinson’s disease related protein which we have shown can be detected in an altered form in the blood of Parkinson’s disease patients. Studies of other potential biomarkers are in progress. I can also initiate, fund and perform projects that particularly interest me in EnCor Biotechnology Inc., my independent privately funded corporate laboratory.
研究兴趣
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Annika Myers,Jonathan Lopez,Afshin Paydar, Kaitlyn Tingus, Timothy VanMeter,Gerry Shaw,Neil Harris,Ina Wanner
JOURNAL OF NEUROTRAUMAno. 15-16 (2023): A135-A136
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JOURNAL OF NEUROTRAUMAno. 15-16 (2023): A23-A23
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Brain communicationsno. 2 (2023)
Adithya Gopinath,Phillip Mackie, Basil Hashimi, Anna Marie Buchanan, Aidan R Smith,Rachel Bouchard,Gerry Shaw, Martin Badov,Leila Saadatpour, Aryn Gittis,Adolfo Ramirez-Zamora, Michael S Okun,
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