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Biokinetics, Effects and Mechanisms of Inhaled Micro- and Nano- Particles: Dosimetry, Risk Extrapolation and Risk Assessment
Our studies with laboratory-generated ultrafine particles have shown that these particles have a significantly greater potency to induce inflammatory lung injury than larger-sized particles with the same chemical composition. Our studies are aimed at investigating cellular and molecular mechanisms of ultrafine particle-induced lung injury as well as secondary effects on the cardiovascular and the central nervous systems. An important component of this research is to develop rodent models with a compromised target organ system to evaluate cellular mechanisms of effects following inhalation exposure. Evaluating translocation pathways of inhaled nano-sized particles after deposition in the respiratory tract to other organ systems is an important part of our studies.
Biokinetics, Effects and Mechanisms of Inhaled Micro- and Nano- Particles: Dosimetry, Risk Extrapolation and Risk Assessment
Our studies with laboratory-generated ultrafine particles have shown that these particles have a significantly greater potency to induce inflammatory lung injury than larger-sized particles with the same chemical composition. Our studies are aimed at investigating cellular and molecular mechanisms of ultrafine particle-induced lung injury as well as secondary effects on the cardiovascular and the central nervous systems. An important component of this research is to develop rodent models with a compromised target organ system to evaluate cellular mechanisms of effects following inhalation exposure. Evaluating translocation pathways of inhaled nano-sized particles after deposition in the respiratory tract to other organ systems is an important part of our studies.
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论文共 32 篇作者统计合作学者相似作者
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Particle and fibre toxicologyno. 1 (2023): 9-17
Particle and Fibre Toxicologyno. 1 (2019)
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