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个人简介
Dra. Gisela Nogales-Gadea obtained her bachelor degree in Biology at the University of Barcelona in July 2002. In the last year of university, she got a competitive fellowship of the Spanish Ministry of Science and Education for collaborating in Genetics Department.
In October 2002, she obtained a fellowship associated to a project funded by ISCIII entitled “Analysis of the genotype-phenotype relation in different forms of amyothophic lateral sclerosis” and with this project she achieved her Master of Science in June 2004.
In January 2005, she started her PhD in the neuromuscular and mitochondrial pathology in Institut de Recerca Vall d´Hebron, working in the coordinated project led by Dr. Antoni Luis Andreu and funded by ISCIII “Molecular and physiological bases modulating the phenotypic expression of myophosphorylase deficiency (McArdle´s disease): development of a knock-in murine model for the p.R50X mutation”. At the beginning of the project, she moved to New York and worked in the neurology department of New-York Presbyterian Hospital under the supervision of Dr. Salvatore DiMauro and Dr. Michio Hirano. During that time, she received 3 research awards: one for the best presented work in the Young Investigators meeting 2008 in Institut de Recerca Vall d´Hebron; and two awards for the team work performed in McArdle disease (one from the Spanish Society of Neurology 2008 and another form the Universidad de Oviedo 2007). In December 2008, she obtained her PhD in Biology with the highest possible qualification, i.e. cum laude.
In January 2009 the candidate started her postdoctoral period with a contract of the Spanish CIBERER for the study of rare diseases. With this contract, the candidate continued the ongoing work started during her PhD in McArdle Disease. One of the biggest candidate's achievements during this period was the publication of the knock-in mice model for McArdle Disease. This mouse model that reproduces genetically and phenotypically McArdle disease will be of utility to unveil unknown aspects of this disease as well as to test new therapies. It is also important to mention that in 2009 the candidate started to participate as an academic editor for the scientific journal Plos One and she is still thoroughly involved in this editorial task.
In January 2011, she obtained a competitive postdoctoral fellowship of the ISCIII in the program Sara Borrell. She joined the neuromuscular disease unit led by Dra. Isabel Illa in Institut de Recerca Hospital de la Santa Creu i Sant Pau, in the project funded by ISCIII “Neuromuscular diseases: immunological aspects relevant for the development of therapeutic strategies”. She got introduced to a new concept of research with a mixed team of clinical and basic researchers working together “bed to bench and back to the bed site”. The research work of these periods was done in different diseases: chronic inflammatory demyelinating polyneuropathy, dermatomyositis and myasthenia gravis. In this period she participated in the discovery and identification of pathological antibodies against contactin-1 and neurofascin-155 in chronic inflammatory demyelinating polyneuropathy, which identified a specific group of patients with severe clinical presentation and similar response to therapies. Also the collaboration initiated during this period with the group of Dr. Catherine Faivre-Sarrailh in the Institut Jean Roche in Marseille France, allowed the study of the pathogenic mechanisms of those antibodies. It is worth to mention, that other important work during that period was the identification of a serum miRNA profile specific for myasthenia gravis patients.
In September 2013 the candidate moved to Maastricth, the Netherlands, in the 1-year exchange period within the Sara Borrell Program ISCIII. She was involved in different projects of Dr. Mario Losen and Dr. Pilar Martinez-Martinez for antibody profile characterization and therapeutic approaches for myasthenia gravis disease.
Currently, she has obtained a research grant to start a line of research in Neuromuscular and Neuropediatric diseases as indepedent researcher, in Institut d'Investigacio Germans Trias i Pujol, Badalona, Barcelona, Spain. This research line is focused in rare diseases, but has choosed to start Myotonic Dystrophies. Currently the lab has 3 active projects: 1) find treatments; 2) find biomarkers; 3) to understand disease pathology at single cell level. To develop these projects the team is mixed by Physicians from Hospital Germans Trias i Pujol (from Neurology and Pediatrics Department) and translational researchers that develop their work in the Institute Germans Trias i Pujol. The team is growing exponentially, we are highly motivated to produce knowledge with significant meaning to improve the life of the patients with these diseases. The group is open to receive new resarchers, so do not hesitate to contact them.
研究兴趣
论文共 88 篇作者统计合作学者相似作者
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Judit Núñez-Manchón, Júlia Capó,Alicia Martínez-Piñeiro, Eduard Juanola,Jovan Pesovic,Laura Mosqueira-Martín,Klaudia González-Imaz, Pau Maestre-Mora, Renato Odria,Dusanka Savic-Pavicevic,Ainara Vallejo-Illarramendi,Kamel Mamchaoui,
iScienceno. 6 (2024): 109930-109930
A. López-Martínez,P. Soblechero-Martín,C. Catalli, A. Jauregui-Barrutia, S. Kapetanovic-Garcia,G. Nogales-Gadea,V. Arechavala-Gomeza
Neuromuscular Disorders (2022): S132-S133
M. Villarreal-Salazar,A. Santalla, A. Real-Martinez,G. Nogales-Gadea,P. L. Valenzuela,C. Fiuza-Luces,A. L. Andreu, J. C. Rodriguez-Aguilera,M. A. Martin,J. Arenas,J. Vissing,A. Lucia,
Molecular metabolism (2022): 101648-101648
Neuromuscular disorders : NMDno. 12 (2021): 1296-1310
Neurology. Geneticsno. 4 (2020): e484-e484
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作者统计
#Papers: 92
#Citation: 2544
H-Index: 24
G-Index: 48
Sociability: 6
Diversity: 0
Activity: 0
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