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Lambeau team is one of the world leading groups focusing on the secreted phospholipase A2 (sPLA2) family of enzymes and their receptor PLA2R1. The laboratory has discovered and cloned PLA2R1, but also many human sPLA2s, and has developed a large array of tools for sPLA2 and PLA2R1 research. Thanks to a number of callaborators, the team has discovered many biological functions of mouse and human sPLA2s, highlighting them as possible drug targets, with translational research in humans, including 15 patents and licensing for 4 of them. Since the last 10 years, the team has co-discovered that PLA2R1 and THSD7A are two major autoantigens in membranous nephropathy (MN), a rare but severe autoimmune kidney disease. Several commercial assays for diagnosis of MN are now available worldwide. Last, the team has identified several PLA2R1 epitopes, leading to a better knowledge of the physiopathological mechanisms of the disease and new biological assays to help better define clinical outcome.
Research Interests
Papers共 247 篇Author StatisticsCo-AuthorSimilar Experts
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crossref(2023)
BIOCHIMIE (2023): 1-3
MAYO CLINIC PROCEEDINGSno. 11 (2023): 1671-1684
MOLECULAR METABOLISM (2023): 101791-101791
Kidney360no. 2 (2023): 217-225
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Author Statistics
#Papers: 246
#Citation: 17883
H-Index: 69
G-Index: 131
Sociability: 7
Diversity: 4
Activity: 52
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