His research activity focus on the theory and phenomenology of fundamental interactions. He provided seminal contributions in the area of Higgs physics and flavor physics, both within and beyond the Standard Model. His most influential results include the demonstration of the metastability of the Standard Model vacuum, the formulation of the hypotheses of Minimal Flavor Violation, and the study of symmetries and symmetry-breaking patterns for theories beyond the Standard Model. Since 2015 his research group at the University of Zurich is playing a leading role in the theoretical interpretation of the B-physics anomalies. In 2019 he has been awared and ERC Advanced Grant by the European Research Council for his research activity in flavor physics. Since 2021 he is a member of the Science Policy Committee of the CERN Laboratory in Geneva.