Dr. Shapiro's practice is based in the Center for Cancer Therapeutic Innovation, where he develops and leads early phase clinical trials primarily focused on cell cycle and DNA repair inhibitor therapeutics and provides mentoring to early career investigators. As Senior Vice President, Developmental Therapeutics, he leads DFCI efforts for National Cancer Institute (NCI)-sponsored clinical trials developed through the Experimental Therapeutics Clinical Trials Network (ETCTN) and works integrally with multiple disease groups within the Institute.