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Bio
The research in my laboratory focuses on the role of host defense peptides in the defense against infectious diseases at mucosal surfaces. Defensins and cathelicidins are two classes of peptides that play important roles in innate immune defenses against microbial pathogens. They exhibit broad-spectrum antimicrobial activity, and also modulate the innate immune system. We are studying them in two different ways: First, we are examining how their genes are regulated in the lung and in the oral cavity, by factors such as vitamin D and cytokines, to develop new ways of treating and preventing infectious diseases. This utilizes both molecular biology approaches with cultured cells as well as in vivo infection models. Second, we are working with a company to develop novel molecules based on these naturally occurring peptides, to treat and prevent oral and systemic microbial infections. This involves quantifying the in vitro activity of these compounds against microbial pathogens, as well as testing then in mouse models of infection.
Research Interests
Papers共 132 篇Author StatisticsCo-AuthorSimilar Experts
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Erika L. Figgins, Payal Arora,Denny Gao, Emily Porcelli, Rabab Ahmed, Carlo Amorin Daep, Garrett Keele,Lisa K. Ryan,Gill Diamond
FRONTIERS IN ORAL HEALTH (2024): 1378566-1378566
Jaclyn M. Long,Vincent N. Miao,Anna H. Owings,Ying Tang,Joshua D. Bromley,Samuel W. Kazer,Kyle Kimler, Chelsea Asare,Carly G. K. Ziegler,Samira Ibrahim, Tasneem Jivanjee,Micayla George,
crossref(2024)
JOURNAL OF FUNGIno. 1 (2024): 54
Microbiology spectrumno. 6 (2024): e0351623-e0351623
ACS infectious diseasesno. 8 (2023): 1508-1522
Frontiers in oral health (2022): 971191
ACS INFECTIOUS DISEASESno. 3 (2022)
Encyclopediano. 4 (2022): 1722-1737
JOURNAL OF IMMUNOLOGYno. 1 (2022)
The 8th International Electronic Conference on Medicinal Chemistry (2022)
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