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The Price lab is presently focusing on the molecular biology and physiology of photosynthesis in cyanobacteria (blue-green photosynthetic bacteria) with emphasis on gaining a full understanding of the adaptive mechanism known as a the 'CO2 concentrating mechanism' in these organisms (CCM). The CCM operates to elevate the CO2 concentration around the otherwise substrate-limited primary carboxylase, Rubisco, thus improving the efficiency of photosynthetic CO2 fixation. The system features inducible and constitutive transporters for CO2 and HCO3- that actively accumulate HCO3- within the cell through a light-dependent process. Accumulated HCO3- then enters a unique polyhedral Rubisco-containing organelle known as a carboxysome. Here CO2 is generated and maintained at a high steady state concentration with the aid of a carbonic anhydrase enzyme that is specifically located in the carboxysome. In addition, a special property of the carboxysome retards CO2 leakage leading to efficient CO2 fixation. We have produced a suite of defined CCM mutants for intensive analysis. Combined with the existence of several complete genome sequence databases for cyanobacteria, plus some modern molecular techniques, we have some powerful resources available for the molecular elucidation of the CCM. A present goal of this work is to allow the engineering of some useful CCM components into higher plants so that water and nitrogen-use efficiency can be improved.
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Science advancesno. 19 (2024): eadk7283-eadk7283
The Plant journal : for cell and molecular biologyno. 4 (2024): 940-952
Sarah Rottet,Loraine M. Rourke,Isaiah C.M. Pabuayon,Su Yin Phua, Suyan Yee, Hiruni N. Weerasooriya, Xiaozhuo Wang, Himanshu S. Mehra,Nghiem D. Nguyen,Benedict M. Long,James V. Moroney,G. Dean Price
biorxiv(2024)
Plant, Cell & Environmentno. 1 (2023): 23-44
Photosynthesis researchno. 2 (2023): 265-277
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