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Research interests
My research group focuses on elucidating the genetic mechanisms of the interaction of the pathogens with the host using avant-garde technologies. Resistance from pathogens to antibiotics or antiparasitic drugs is a growing concern and affects millions patients worldwide every year. There is an urgent need to find novel treatment to improve the care of people as bacteria or parasites are becoming resistant to all existing antibiotics and antiparasitic agents. Novel & innovative strategies are desperately needed for this problem. In the general population, there are individual differences between humans that give some people an advantage in their ability to resist severe disease caused by infections. My group aim to understand why these people are resistant to pathogens using mouse as a model. Using genomic technologies (DNA and RNA sequencing), advanced mouse genetic technologies (ENU mutagenesis in mice, Collaborative Cross in mice) or transgenesis technologies such as CRISPR/Cas9 mediated genome editing in mice or pathogens, we aim to dissect mechanisms of the host resistance to pathogens (hospital acquired infection as well as malaria) as well as the mechanisms of interaction of the pathogens to the host.
My research group focuses on elucidating the genetic mechanisms of the interaction of the pathogens with the host using avant-garde technologies. Resistance from pathogens to antibiotics or antiparasitic drugs is a growing concern and affects millions patients worldwide every year. There is an urgent need to find novel treatment to improve the care of people as bacteria or parasites are becoming resistant to all existing antibiotics and antiparasitic agents. Novel & innovative strategies are desperately needed for this problem. In the general population, there are individual differences between humans that give some people an advantage in their ability to resist severe disease caused by infections. My group aim to understand why these people are resistant to pathogens using mouse as a model. Using genomic technologies (DNA and RNA sequencing), advanced mouse genetic technologies (ENU mutagenesis in mice, Collaborative Cross in mice) or transgenesis technologies such as CRISPR/Cas9 mediated genome editing in mice or pathogens, we aim to dissect mechanisms of the host resistance to pathogens (hospital acquired infection as well as malaria) as well as the mechanisms of interaction of the pathogens to the host.
Research Interests
Papers共 96 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
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P. Acera Mateos,A.J. Sethi,A. Ravindran,A. Srivastava, M. Kanchi, S. Mahmud,M. Guarnacci,K. Woodward,J. Xu,Z.W.S. Yuen,Y. Zhou,A. Sneddon,
bioRxiv (Cold Spring Harbor Laboratory) (2024)
Arti Medhavy,Vicki Athanasopoulos, Katharine Bassett,Yuke He,Maurice Stanley, Daniel Enosi Tuipulotu,Jean Cappello, Grant J Brown,Paula Gonzalez-Figueroa,Cynthia Turnbull,Somasundhari Shanmuganandam,Padmaja Tummala,
Nature immunology (2024)
P Acera Mateos,A J Sethi,A Ravindran,A Srivastava,K Woodward, S Mahmud, M Kanchi,M Guarnacci,J Xu,Z W S Yuen,Y Zhou,A Sneddon,
Nature communicationsno. 1 (2024): 3899-3899
P. Acera Mateos,A.J. Sethi,A. Ravindran,A. Srivastava,K. Woodward, S. Mahmud, M. Kanchi,M. Guarnacci,J. Xu,Z.W.S. Yuen,Y. Zhou,A. Sneddon,
bioRxiv (Cold Spring Harbor Laboratory) (2024)
Yaoyuan Zhang,Rhiannon Morris, Grant J. Brown,Ayla May D. Lorenzo,Xiangpeng Meng,Nadia J. Kershaw,Pamudika Kiridena,Gaetan Burgio, Simon Gross,Jean Y. Cappello,Qian Shen,Hao Wang,
JOURNAL OF EXPERIMENTAL MEDICINEno. 4 (2024)
PLOS ONEno. 10 (2023): e0292924-e0292924
Arthritis & Rheumatologyno. 6 (2023): 1058-1071
IRF International Consortium,Oriol Fornes,Alicia Jia,Hye Sun Kuehn,Qing Min,Ulrich Pannicke,Nikolai Schleussner,Romane Thouenon,Zhijia Yu, María de Los Angeles Astbury,Catherine M Biggs,Miguel Galicchio,
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Author Statistics
#Papers: 102
#Citation: 4502
H-Index: 26
G-Index: 66
Sociability: 7
Diversity: 0
Activity: 1
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