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个人简介
Dr. Pike investigates magnetic resonance imaging (MRI) methods and applications for basic and clinical neuroscience research. As a primary focus, he detects and measures the physiological modulations that are associated in neuronal activation and inhibition. This technique is called functional MRI. It can detect changes in blood oxygenation and tissue perfusion with a high temporal and spatial resolution.
It also provides a powerful tool for studying brain physiology in health and disease. Recently, he used his methods to determine, for the first time, the relationship between regional cerebral blood flow and oxygen metabolism in the cortex over a broad range of activation and inhibition conditions in healthy subjects as well as patients with epilepsy, stroke, and Moyamoya disease. He has also developed a in vivo quantitative MR technique term quantitative magnetization transfer (aMT) imaging that probes the magnetic interaction between macromolecules and water. Using MT imaging, his group has revealed focal pathology in multiple sclerosis (MS) patients that precedes the development of conventional MRI visible MS lesions by up to 2 years. His most recent project is the establishment of an MR guided focused ultrasound program. This program has 3 research themes: neurosurgery, drug delivery, and neuromodulation. Dr. Pike has published more than 350 scientific papers and book chapters.
It also provides a powerful tool for studying brain physiology in health and disease. Recently, he used his methods to determine, for the first time, the relationship between regional cerebral blood flow and oxygen metabolism in the cortex over a broad range of activation and inhibition conditions in healthy subjects as well as patients with epilepsy, stroke, and Moyamoya disease. He has also developed a in vivo quantitative MR technique term quantitative magnetization transfer (aMT) imaging that probes the magnetic interaction between macromolecules and water. Using MT imaging, his group has revealed focal pathology in multiple sclerosis (MS) patients that precedes the development of conventional MRI visible MS lesions by up to 2 years. His most recent project is the establishment of an MR guided focused ultrasound program. This program has 3 research themes: neurosurgery, drug delivery, and neuromodulation. Dr. Pike has published more than 350 scientific papers and book chapters.
研究兴趣
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Medical image analysis (2024): 103160-103160
Yunyan Zhang,Wei-Qiao Liu, Zahra Hosseinpour,G. Bruce Pike, Graziela Cerchiaro, Jamie Greenfield,V. Wee Yong,Luanne M. Metz
Multiple Sclerosis and Related Disorders (2024): 105525-105525
Ali K.Zadeh, Hrishikesh Raghuram, Shirshak Shrestha,Mekale Kibreab, Iris Kathol,Davide Martino,G. Bruce Pike,Samuel Pichardo,Oury Monchi
medRxiv (Cold Spring Harbor Laboratory)no. 4 (2023): n/a-n/a
Life (Basel, Switzerland)no. 2 (2023): 500-500
Frontiers in Neuroscience (2023): 1139196-1139196
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