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My research program is targeted to define mechanisms and approaches to induce a state of long-term tolerance in transplant patients. Our work grew out of the basic science in which we identified the unique Treg immunosuppressive molecule fibrinogen like protein 2 (FGL2). Through industry and academic collaborations, we have shown the relevance of fgl2 to the pathogenesis of viral disease, cancer and transplantation. We have now entered into partnership agreements to establish ELISA assays for both human and fgl2 which can be used to detect fgl2 in the plasma/serum of cancer patients and transplant patients. Industry partnerships are now examining the potential utility of an antibody to fgl2 as a cancer checkpoint inhibitor.
Research Interests
Papers共 448 篇Author StatisticsCo-AuthorSimilar Experts
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Scientific Reportsno. 1 (2024): 787-787
PROGRESS IN TRANSPLANTATIONno. 4 (2023): 328-334
Hassan Sadozai,Vanessa Rojas-Luengas,Kaveh Farrokhi,Sajad Moshkelgosha, Qinli Guo,Wei He,Angela Li, Jianhua Zhang,Conan Chua,Dario Ferri, Muhtashim Mian,Oyedele Adeyi,
CLINICAL AND EXPERIMENTAL IMMUNOLOGYno. 1 (2023): 138-154
Senthilkumar Preethy,Naoki Yamamoto, Kottoorathu Mammen Cherian, Rajasekaran Premsekar,Gary A Levy,Rajappa Senthilkumar,Samuel JK Abraham
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Redox biology (2022): 102508-102508
BMJ Open Gastroenterologyno. 1 (2022): e000985-e000985
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Author Statistics
#Papers: 451
#Citation: 15797
H-Index: 71
G-Index: 71
Sociability: 8
Diversity: 3
Activity: 7
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