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The Menard lab works at the interface between chemistry and biology—we use small molecules to study and manipulate biological systems. The group provides a multidisciplinary environment where students and researchers work together to develop new chemical and biophysical tools for the study of living systems.
Our research is focused on the design of molecular tools to study the real-time dynamics of signaling proteins, with a strong emphasis on glial cells and astrocytes in particular. We use natural products as both starting point and inspiration in a unique chemical biology approach. We modify molecules to serve for the selective delivery of biophysicial reporter labels (imaging tags, photoaffinity labels, etc.)
The chemistry we develop is focused on molecular probes and biologically compatible reactions that can work efficiently in living systems. Design of the probes involves modern organic synthesis to modify molecules that are known ligands for a given protein. We also rely on physical organic chemistry principles to create reactions that can take place in the aqueous milieu that is the native cellular environment. As a general strategy, we exploit the innate selectivity of natural products that have been evolved by Nature to target specific proteins.
The biology questions we investigate focus on the interactions between astrocytes and neurons. In particular, we are working to unravel the role of key membrane protein through structural and functional studies. To answer these questions, we combine several techniques that range from molecular biology to electrophysiology and confocal imaging.
The Menard lab works at the interface between chemistry and biology—we use small molecules to study and manipulate biological systems. The group provides a multidisciplinary environment where students and researchers work together to develop new chemical and biophysical tools for the study of living systems.
Our research is focused on the design of molecular tools to study the real-time dynamics of signaling proteins, with a strong emphasis on glial cells and astrocytes in particular. We use natural products as both starting point and inspiration in a unique chemical biology approach. We modify molecules to serve for the selective delivery of biophysicial reporter labels (imaging tags, photoaffinity labels, etc.)
The chemistry we develop is focused on molecular probes and biologically compatible reactions that can work efficiently in living systems. Design of the probes involves modern organic synthesis to modify molecules that are known ligands for a given protein. We also rely on physical organic chemistry principles to create reactions that can take place in the aqueous milieu that is the native cellular environment. As a general strategy, we exploit the innate selectivity of natural products that have been evolved by Nature to target specific proteins.
The biology questions we investigate focus on the interactions between astrocytes and neurons. In particular, we are working to unravel the role of key membrane protein through structural and functional studies. To answer these questions, we combine several techniques that range from molecular biology to electrophysiology and confocal imaging.
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CANADIAN JOURNAL OF CHEMISTRYno. 4 (2024): 180-186
semanticscholar(2020)
semanticscholar(2020)
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