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To better understand how jumping genes play a role in brain function, Gage and his colleagues have investigated the genetic underpinnings of Rett syndrome, a rare neurodevelopmental disease that affects mostly girls and is considered one of the autism spectrum disorders. Typical features of the disorder include loss of speech, stereotypic movements, mental retardation and social behavioral problems. Although almost all cases are caused by a mutation in the MeCP2 gene, how severely people are affected by the symptoms of Rett syndrome varies widely.
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Bang-An Wang,Jeffrey R. Jones,Jingtian Zhou,Wei Tian, Yue Wu,Wenliang Wang,Peter Berube,Anna Bartlett,Rosa Castanon,Joseph R. Nery,Huaming Chen, Mia Kenworthy,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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HIPPOCAMPUSno. 4 (2023): 269-270
Frontiers in Dementia (2023)
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
W. Sharon Zheng,Yajun Zhang, Roger E. Zhu,Peng Zhang,Smriti Gupta,Limeng Huang, Deepika Sahoo,Kaiming Guo,Matthew E. Glover,Krishna C. Vadodaria,Mengyao Li,Tongrui Qian,
bioRxiv (2022)
biorxiv(2022)
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