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RiemannphotoIntestinal hormone secretion and action
The intestinal epithelium is scattered with enteroendocrine cells , which, although only accounting for less than 1% of this tissue, can be considered the biggest endocrine organ in the body. Some of the peptides secreted have important regulatory roles for metabolism; glucagon-like peptide-1 for example boosts postprandial insulin secretion and is the basis for mimetics with improved plasma half-life now widely used in the treatment of diabetes. GLP-1 and the co-secreted polypeptide YY also reduce food intake, and elevated plasma levels of these hormones correlate with the positive effects of gastric bypass surgery for the treatment of obesity.
RiemannphotoIntestinal hormone secretion and action
The intestinal epithelium is scattered with enteroendocrine cells , which, although only accounting for less than 1% of this tissue, can be considered the biggest endocrine organ in the body. Some of the peptides secreted have important regulatory roles for metabolism; glucagon-like peptide-1 for example boosts postprandial insulin secretion and is the basis for mimetics with improved plasma half-life now widely used in the treatment of diabetes. GLP-1 and the co-secreted polypeptide YY also reduce food intake, and elevated plasma levels of these hormones correlate with the positive effects of gastric bypass surgery for the treatment of obesity.
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crossref(2023)
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Pei-En Chung, J. Zhang,Mariana Norton, Leah Meyer, Cecilia Dunsterville, Jieruo Liu,Fiona M. Gribble,Frank Reimann,Wenhan Chang,Kevin M. Murphy
Endocrine Abstracts (2023)
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