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Determining a protein’s three dimensional structure — the position of each of its tens of thousands of atoms — is a key challenge in biochemistry. While many known protein structures were solved using high-resolution techniques, such as X-ray crystallography, for many interesting and biomedically relevant proteins, we can only collect sparse experimental information. That is, we may collect information describing the proteins conformation, but not enough information to uniquely place every atom. Our lab is interested in developing novel computational tools to determine high-resolution structures using only low-resolution data. Key to this is drawing information from the tens of thousands of previously solved structures.
Determining a protein’s three dimensional structure — the position of each of its tens of thousands of atoms — is a key challenge in biochemistry. While many known protein structures were solved using high-resolution techniques, such as X-ray crystallography, for many interesting and biomedically relevant proteins, we can only collect sparse experimental information. That is, we may collect information describing the proteins conformation, but not enough information to uniquely place every atom. Our lab is interested in developing novel computational tools to determine high-resolution structures using only low-resolution data. Key to this is drawing information from the tens of thousands of previously solved structures.
Research Interests
Papers共 236 篇Author StatisticsCo-AuthorSimilar Experts
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Qinqin Zhao,Savannah Bertolli,Young-Jun Park,Yongjun Tan,Kevin J Cutler,Pooja Srinivas,Kyle L Asfahl, Citlali Fonesca-García,Larry A Gallagher,Yaqiao Li,Yaxi Wang,Devin Coleman-Derr,
Natureno. 8010 (2024): 165-173
Nature Methodsno. 1 (2024): 117-121
PLoS computational biologyno. 6 (2024): e1011895-e1011895
crossref(2024)
Journal of Molecular Biologypp.168546-168546, (2024)
NATURE NANOTECHNOLOGYpp.1-6, (2024)
Catherine L Lawson,Andriy Kryshtafovych,Grigore D Pintilie, Stephen K Burley,Jiří Černý,Vincent B Chen,Paul Emsley,Alberto Gobbi, Andrzej Joachimiak,Sigrid Noreng, Michael Prisant,Randy J Read,
Research squarepp.1-9, (2024)
Frank DiMaio, Ryan McHugh
NATURE METHODSno. 1 (2024)
Structure (London, England : 1993)no. 7 (2023): 860-869.e4
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