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个人简介
I am a Professor of Medicine at Harvard Medical School (HMS) and the Director of the Medical Chronobiology Program (MCP) at Brigham and Women’s Hospital (BWH). My research is primarily focused on medical chronobiology, including investigations of the underlying physiological mechanisms and therapeutic strategies to treat chronobiological disorders.
My lab is focused on the influence of the endogenous circadian system and its disruption—such as with shift work—on cardiovascular, pulmonary, and metabolic regulation and disease states, including hypertension, asthma, obesity and diabetes. This, primarily, basic and translational human research is aimed both at the physiological mechanisms and therapeutic strategies of medical chronobiology.
I have co-founded and currently direct the MCP, an interdisciplinary research program at BWH to foster the translational research in sleep and circadian biology to understand the basis behind time-variant changes in disease severity, the effects of circadian misalignment (typical in night shift workers), and their interaction with genetics (e.g., the common MTNR1B variant).
Understanding the biological basis of these changes across the day and night and their interaction with genetics may help in the development of personalized and time-based behavioral, environmental, and pharmaceutical interventions (e.g. appropriately timed meals, exercise or melatonin to target specific phases of the body clock) to prevent, treat, and/or manage disease.
研究兴趣
论文共 269 篇作者统计合作学者相似作者
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JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCESno. 3 (2024)
H. Craig Heller,Erik Herzog,Allison Brager,Gina Poe,Ravi Allada,Frank Scheer,Mary Carskadon,Horacio O. de la Iglesia, Rockelle Jang,Ashley Montero,Kenneth Wright, Philippe Mouraine,
JOURNAL OF BIOLOGICAL RHYTHMSno. 1 (2024): 5-19
Proceedings of the National Academy of Sciences of the United States of Americano. 9 (2024): e2214756121-e2214756121
Elizabeth B Klerman,Kenneth P Wright,Jeanne F Duffy,Frank A J L Scheer,Anne-Marie Chang,Charles A Czeisler, Shantha Mw Rajaratnam
Sleep healthno. 1S (2024): S4-S10
Danielle A. Wallace,Kelly R. Evenson,Carmen R. Isasi, Sanjay Patel,Daniela Sotres-Alvarez,Phyllis C. Zee, Susan Redline,Frank A.J.L. Scheer,Tamar Sofer
crossref(2024)
International Journal of Obesityno. 5 (2024): 1-1
OBESITY REVIEWSno. 3 (2024): e13664-e13664
Marvin Y. Chong, Koen G. Frenken,Simone J. P. M. Eussen,Annemarie Koster,Gerda K. Pot,Stéphanie O. Breukink,Maryska Janssen-Heijnen,Eric T. P. Keulen,Wouter Bijnens, Laurien M. Buffart,Kenneth Meijer,Frank A. J. L. Scheer,
International Journal of Behavioral Nutrition and Physical Activityno. 1 (2024): 1-15
ENVIRONMENTAL POLLUTION (2024): 123258-123258
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