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RESEARCH INTERESTS:
1. Mechanisms of insulin action, resistance and -cell failure. Pathogenesis of non-insulindependent diabetes mellitus (T2DM).
2. Clinical-mechanistic trials of new pharmacological treatments and bariatric surgeries for the preventions and treatment of type 2 and type 1 diabetes mellitus and their complications.
3. Pathogenesis of insulin-dependent diabetes mellitus (T1DM) and Stiff-man syndrome.
4. Biology of regulated secretion in the endocrine pancreas and central nervous system
5. Pathogenesis of diabetic vascular complications
6. Central nervous system paraneoplastic syndromes
7. Tyrosine kinases and mechanisms of intracellular signal transduction
8. Proteomics approach to assess regulation in protein expression in diabetes mellitus and associated disease states
9. Development of non-human primate models for the study and development of novel therapeutic approaches of obesity, insulin resistance and type 2 diabetes mellitus
10. Mechanisms of action of GLP-1 receptor agonists in humans and non-human primate models of type 2 diabetes mellitus.
11. Morbid obesity, molecular mechanisms of pathogenesis, prevention and treatment.
1. Mechanisms of insulin action, resistance and -cell failure. Pathogenesis of non-insulindependent diabetes mellitus (T2DM).
2. Clinical-mechanistic trials of new pharmacological treatments and bariatric surgeries for the preventions and treatment of type 2 and type 1 diabetes mellitus and their complications.
3. Pathogenesis of insulin-dependent diabetes mellitus (T1DM) and Stiff-man syndrome.
4. Biology of regulated secretion in the endocrine pancreas and central nervous system
5. Pathogenesis of diabetic vascular complications
6. Central nervous system paraneoplastic syndromes
7. Tyrosine kinases and mechanisms of intracellular signal transduction
8. Proteomics approach to assess regulation in protein expression in diabetes mellitus and associated disease states
9. Development of non-human primate models for the study and development of novel therapeutic approaches of obesity, insulin resistance and type 2 diabetes mellitus
10. Mechanisms of action of GLP-1 receptor agonists in humans and non-human primate models of type 2 diabetes mellitus.
11. Morbid obesity, molecular mechanisms of pathogenesis, prevention and treatment.
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