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个人简介
I have been part of the scientific team at the Príncipe Felipe Research Center in Valencia for 15 years, where our objective is the resolution of clinical and biological problems with computational approaches, fundamentally within the framework of Biomedicine and with a clear translational character to clinical practice.
Our Computational Biomedicine Laboratory aims to develop innovative methods and tools for the big data analysis from different sources in Biomedicine, which allow us a better characterization of diseases and their treatments. The main lines of work are focused on:
1) Improving the understanding of molecular mechanisms in neuronal pathologies:
- Generation of single-cell atlases to decipher sex differences in neurodegenerative diseases (Parkinson’s disease, Alzheimer’s disease and multiple sclerosis)
- Identification of biological pathways in behavioural alteration pathologies (schizophrenia and autism spectrum disorder)
- Detection of transcriptomic signatures for the understanding of molecular mechanisms associated with spinal cord injury
- Study of differential sex profiles in neuroinflammation associated with alcohol use disorders, through integrative multi-omics strategies.
2) Finding novel biomarkers in cancer:
- Development and application of big-data analysis methods for the identification of novel diagnostic and progression biomarkers in cancer studies
- Neurobiology of cancer: description of the role of the nervous system in oncological diseases and identification of possible clinical implications in oncology. Identifying transcriptomic signatures shared between neurodegenerative diseases and brain metastatic melanoma.
3) Clinical targets and predictors in metabolic disorders:
- Detection of potential clinical targets in obesity, diabetes and MAFLD (metabolic associated fatty liver disease) through massive analysis of omics data
- Clinical predictors based on high-throughput technologies and artificial intelligence methods.
研究兴趣
论文共 305 篇作者统计合作学者相似作者
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Fabio A. Quiñónez Bareiro,José A. Carnicero, Ana Alfaro Acha, Cristina Rosado Artalejo, María C. Grau Jimenez, Leocadio Rodriguez Mañas,Francisco J. García García
GeroSciencepp.1-13, (2024)
Journal of cellular and molecular medicineno. 8 (2024): e18153-e18153
JOURNAL OF CELLULAR AND MOLECULAR MEDICINEno. 8 (2024)
Biology of Sex Differencesno. 1 (2024): 1-19
Translational Exercise Biomedicineno. 0 (2024)
Jaime Llera-Oyola,Héctor Carceller,Zoraida Andreu,Marta R. Hidalgo,Irene Soler-Sáez,Fernando Gordillo, Borja Gómez-Cabañes,Beatriz Roson,Maria de la Iglesia-Vayá,Roberta Mancuso, Franca R. Guerini,Akiko Mizokami,
Biology of Sex Differencesno. 1 (2024): 1-14
Adolfo López-Cerdán,Zoraida Andreu, Marta R. Hidalgo,Irene Soler-Sáez,María de la Iglesia-Vayá, Akiko Mikozami, Franca R. Guerini,Francisco García-García
Neurobiology of Disease (2024): 106605-106605
Fabio A. Quiñónez Bareiro,José A. Carnicero, Ana Alfaro Acha, Cristina Rosado Artalejo, María C. Grau Jimenez,Leocadio Rodriguez Mañas,Francisco J. García García
GeroScienceno. 1 (2024): 609-620
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