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个人简介
I became interested in oncology when I was a medical student at the Medical School of the University of Naples, Naples, Italy. For this reason, I spent some elective time in the laboratory of Cytometry at the Department of Clinical and Molecular Oncology of the University of Naples Medical School. I participated in studies that investigated the synergistic effects and mechanisms of action of novel inhibitors in human cancer cell lines, and the potential role as a biomarker of cell cycle alterations in rectal carcinoma. After my master degree in Medicine and Surgery in 2005, I applied for the Residency in clinical oncology at the Department of Clinical and Molecular Oncology of the University of Naples, under the supervision of my mentor Prof S. Pepe. During the period of my Residency I was mainly involved in the treatment of cancer patients, but I continued to spend part of my time in his laboratory focusing my research on a novel combinatorial strategy for the treatment of glioblatoma. For this project I was awarded in 2007 at the 25th National Conference of Cytometry. Furthermore I started to build collaboration with other researchers, investigating the potential role of specific loco-regional approaches and ultrasound technique for the treatment of hepatocellular carcinoma.
Although my clinical training was completed, I realized that I needed training in basic science in order to be able to address clinically relevant questions in an effective and informative way. Because my long range goal is to develop a competitive translational research program focused on immunotherapy of solid tumors in an academic Institution, after a short experience as an attending physician I decided to apply for a PhD program in Molecular Oncology at University of Naples. During this program in order I also realized that to increase my research skills I needed to complete my training outside my Country, in a laboratory which applies basic science to clinical problems in solid tumors. For this reason in 2011 I moved in Dr. S. Ferrone laboratory at the University of Pittsburgh Cancer Institute in Pittsburgh, PA (USA). Dr. Ferrone laboratory had investigated mechanisms utilized by cancer cells to escape from immune destruction and had shown that some cancer cells express specific tumor antigens which can be used as a target for immunotherapy. I was involved in several projects. One of them focused on the characterization of the molecular basis of resistance to BRAF inhibitor of melanoma cells with BRAF mutation. Another project focused on the characterization of the anti tumor activity of a novel immunotherapeutic strategy in ovarian cancer. With these studies I obtained informative results as demonstrated by the award I received in 2013 at MGH. However my interest continued to be on the development of novel immunotherapy for the treatment of solid tumors.
In summary by my clinical training, by investigating many types of tumors in vitro and in vivo during my scientific training, by working with outstanding investigators, by working in great environments such as the University of Naples, the University of Pittsburgh and the Massachusetts General Hospital, and by interacting with several investigators abroad the word I have acquired a good background in tumor oncology and immunology which allows me to develop novel potential strategies for the treatment of solid tumors.
研究兴趣
论文共 124 篇作者统计合作学者相似作者
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Cancer letters (2024): 216713-216713
Alessandro Ottaiano,Mariachiara Santorsola,Monica Ianniello,Anna Ceccarelli,Marika Casillo,Francesco Sabbatino,Nadia Petrillo, Marco Cascella, Francesco Caraglia,Carmine Picone, Francesco Perri,Roberto Sirica,
Journal of Translational Medicineno. 1 (2024): 1-11
Valeria Conti,Nicola Bertini, Rosaria Ricciardi,Berenice Stefanelli,Emanuela De Bellis,Carmine Sellitto, Marco Cascella,Francesco Sabbatino,Graziamaria Corbi,Pasquale Pagliano,Amelia Filippelli
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGYno. 4 (2024): 275-292
Alessandro Ottaiano,Mariachiara Santorsola,Monica Ianniello,Anna Ceccarelli,Marika Casillo,Francesco Sabbatino,Nadia Petrillo, Marco Cascella, Francesco Caraglia,Carmine Picone, Francesco Perri,Roberto Sirica,
Alessandro Ottaiano,Mariachiara Santorsola,Monica Ianniello,Anna Ceccarelli,Marika Casillo,Francesco Sabbatino,Nadia Petrillo, Marco Cascella, Francesco Caraglia,Carmine Picone, Francesco Perri,Roberto Sirica,
JOURNAL OF TRANSLATIONAL MEDICINEno. 1 (2024)
MOLECULAR CANCERno. 1 (2024)
Surgical Pathology Clinics (2024)
Alessandro Ottaiano,Mariachiara Santorsola,Monica Ianniello,Anna Ceccarelli,Marika Casillo,Francesco Sabbatino,Nadia Petrillo, Marco Cascella, Francesco Caraglia,Carmine Picone, Francesco Perri,Roberto Sirica,
Mariachiara Santorsola,Maurizio Capuozzo,Guglielmo Nasti,Francesco Sabbatino,Annabella Di Mauro, Giordana Di Mauro,Gianluca Vanni,Piera Maiolino,Marco Correra, Vincenza Granata,Oreste Gualillo,Massimiliano Berretta,
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