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Bio
Françoise Bachelerie (FB) is a Virologist with a strong interest in Host/Virus interactions and a pharmacologist recognized
for her expertise and pioneer works in the field of chemokine and chemokine receptors biological and pathological functions, for which she made important breakthroughs regarding the CXCL12/CXCR4/CXCR7 trio. FB notably contributed to the discovery that the chemokine CXCL12 is the ligand for the CXCR4 receptor and can thus prevent infection by the Human Immunodeficiency Virus (HIV). FB’ team identified the orphan CXCR7/ACKR3 receptor as being the 2nd receptor for CXCL12 that behaves as a modulator of CXCL12/CXCR4 functions. FB belongs to various international committees in the field including the one that reviewed the standard nomenclature for chemokine receptors that are categorized into a large subgroup of G protein–coupled (GPCR) leukocyte chemotactic receptors (including CXCR4), and a smaller subgroup of atypical chemokine receptors (including the CXCR7/ACKR3) (i.e. International Union of Pharmacology). FB’ team provided original evidence that the only natural polymorphism of CXCR4 known up to date and resulting in a gain of function, is responsible for the clinical manifestations of the rare WHIM primary immunodeficiency being a pan-leukopenia and a severe Human Papillomavirus (HPV)-induced pathogenesis. Current projects (Coll; IGF Montpellier) are dedicated at understanding the activation/function of the CXCL12/CXCR4-CXCR7 trio and of key cell effectors of the immune system (e.g. Dendritic cells, B and T cells) including their role in the pathogenesis of immunological disorders (e.g. WHIM syndrome) and in the innate intrinsic control of the life-cycle of HPV, viruses that belong to the human commensal virome while displaying oncogenic potential when they persist. Expertise of our team cover from structural and functional studies in cell and animal models to ex-vivo studies of human samples through combined targeted (functional and phenotypic assays) and unbiased profiling (transcriptomic, proteomic) approaches. We set up experimental model of the WHIM syndrome and HPV life-cycle and oncogenesis in which is investigated the potential therapeutic properties of antagonists of the CXCL12-axis developed with chemists (coll. ESBS and Univ. of Pharmacy, Illkirch and Châtenay-Malabry FR).
Research Interests
Papers共 133 篇Author StatisticsCo-AuthorSimilar Experts
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crossref(2024)
New England Journal of Medicineno. 14 (2024): 1339-1341
BRITISH JOURNAL OF HAEMATOLOGYno. 4 (2024): 1383-1392
JOURNAL OF IMMUNOLOGYno. 12 (2023): 1913-1924
IUPHAR/BPS guide to pharmacology CITEno. 1 (2023)
Frontiers in cellular and infection microbiology (2023): 1138232
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Clément Dominguez-Lafage,Marta Laganà,Franck Gesbert,Viviana Marin-Esteban,Géraldine Schlecht-Louf,Françoise Bachelerie,Claire Deback
bioRxiv (Cold Spring Harbor Laboratory) (2022)
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Author Statistics
#Papers: 135
#Citation: 13325
H-Index: 41
G-Index: 94
Sociability: 7
Diversity: 3
Activity: 43
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