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The neuropathological correlates of Alzheimer’s disease (AD) include amyloid-ß (Aß) plaques and tau-laden neurofibrillary tangles. Although it has been possible to develop transgenic mice that develop one of these lesions, it has proven to be quite challenging to develop mice with both histopathological lesions in the same mouse, in AD-relevant brain regions such as the hippocampus and cortex. To better model AD neuropathology, my lab utilized a novel approach to create a triple transgenic model of AD (3xTg-AD). Rather than crossing independent lines, we microinjected two transgenes (ßAPP and tau) into single-cell embryos from homozygous PS1M146V knockin mice, generating mice with the same genetic background.
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ALZHEIMERS & DEMENTIAno. 4 (2024): 2922-2942
Tee Jong Huat, Judith Camats-Perna,Estella A Newcombe, Tessa Onraet, Daniel Campbell, Josiah T Sucic, Alessandra Martini, Stefânia Forner, Mehdi Mirzaei, Wayne Poon,Frank M LaFerla,Rodrigo Medeiros
Scientific reportsno. 1 (2024): 14305-14305
Kristine M Tran, Nellie Kwang,Angela Gomez-Arboledas,Shimako Kawauchi, Cassandra Mar, Donna Chao,Celia Da Cunha,Shuling Wang, Sherilyn Collins, Amber Walker, Kai-Xuan Shi,Joshua A Alcantara,
bioRxiv : the preprint server for biology (2024)
Laura Fernandez Garcia‐Agudo, Zechuan Shi,Ian F. Smith,Enikö A. Kramár,Katelynn Tran,Shimako Kawauchi,Shuling Wang, Sherilyn Collins,Amber Walker, Kai‐Xuan Shi,Jonathan Neumann,Heidi Yahan Liang,
Alzheimer's & Dementia (2024)
Mathew Blurton-Jones,Brian Spencer, Sara Michael,Nicholas A. Castello, Andranik A. Agazaryan,Joy L. Davis, Franz-Josef Mueller,Jeanne F. Loring,Eliezer Masliah,Frank M. Laferla
STEM CELL RESEARCH & THERAPYno. 1 (2024)
Claire A Butler, Adrian Mendoza Arvilla,Giedre Milinkeviciute,Celia Da Cunha,Shimako Kawauchi,Narges Rezaie,Heidi Y Liang,Dominic Javonillo, Annie Thach,Shuling Wang, Sherilyn Collins,Amber Walker,
Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
ALZHEIMERS & DEMENTIA (2024)
Mathew Blurton-Jones,Brian Spencer, Sara Michael,Nicholas A. Castello, Andranik A. Agazaryan,Joy L. Davis,Franz-Josef Müller,Jeanne F. Loring,Eliezer Masliah,Frank M. LaFerla
Stem Cell Research & Therapyno. 1 (2024): 1-2
Claire A. Butler, Adrian Mendoza Arvilla,Giedre Milinkeviciute,Celia Da Cunha,Shimako Kawauchi,Narges Rezaie,Heidi Y. Liang,Dominic Javonillo, Annie Thach,Shuling Wang,Sherilyn Collins,Amber Walker,
ALZHEIMERS & DEMENTIA (2024)
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