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Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. She spent few years as Neuropharmacology Fellow at NIH, trained in clinical psychiatry at Yale, and then was a Research Fellow in developmental genetics at the Yale School of Medicine, where she raised through the ranks to Assistant, Associate and full Professor. Vaccarino leads a multidisciplinary research group working towards new directions for the study of mammalian brain development, particularly human, using stem cell biology and genomics as tools. She has been studying brain development in animal models for over 20 years, focusing on the role of growth factor receptor signaling in the regulation of stem cell behavior and cerebral cortex morphogenesis. Inspired by Sasai’s work, Vaccarino and her lab pioneered the generation of 3D brain organoids from induced pluripotent stem cells (iPSCs) in 2012, and showed that they recapitulate early fetal development of the human cerebral cortex. They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She participates to the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studies somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE and the Brain Somatic Mosaicism Consortia.
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论文共 186 篇作者统计合作学者相似作者
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Soraya Scuderi,Tae-Yun Kang,Alexandre Jourdon, Liang Yang,Feinan Wu, Alex Nelson, George M Anderson,Jessica Mariani,Vivekananda Sarangi,Alexej Abyzov,Andre Levchenko,Flora M Vaccarino
bioRxiv : the preprint server for biology (2024)
Xoel Mato-Blanco,Suel-Kee Kim, Alexandre Jourdon,Shaojie Ma,Andrew T N Tebbenkamp,Fuchen Liu, Alvaro Duque,Flora M Vaccarino,Nenad Sestan,Carlo Colantuoni,Pasko Rakic, Gabriel Santpere,
bioRxiv : the preprint server for biology (2024)
Science (New York, N.Y.)no. 6698 (2024): eadh0559-eadh0559
Yifan Wang,Liana Fasching, Feinan Wu, Anita Huttner,Sabina Berretta, Rosalinda Roberts, James F Leckman, Alexej Abyzov,Flora M Vaccarino
bioRxiv : the preprint server for biology (2024)
bioRxiv : the preprint server for biology (2024)
Davide Capauto,Yifan Wang, Feinan Wu,Scott Norton,Jessica Mariani,Fumitaka Inoue,Gregory E. Crawford,Nadav Ahituv, Alexej Abyzov,Flora M. Vaccarino
SCIENTIFIC REPORTSno. 1 (2024): 3936-3936
Scientific datano. 1 (2023): 813-813
biorxiv(2023)
NATURE NEUROSCIENCE (2023)
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