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Frank Castellino and Victoria Ploplis of the W.M. Keck Center for Transgene Research are using mice to study the mechanisms by which components of the hemostasis system regulate the initiation and progression of cancer. Earlier studies have identified a relationship between the regulation of the hemostasis system and tumor growth and metastasis. While it has been shown that elevated levels of proteins of this system are associated with carcinomas of breast, colon, skin, prostate, lung, kidney, and brain, the specific mechanisms by which they contribute to this disease process are still unclear.
By using a colon cancer model in which genetic mutations and deficiencies of hemostasis genes have been introduced in the mouse genome, Keck Center researchers are determining the effects these alterations have on tumor initiation, growth, angiogenesis, and metastasis. Initial studies at the Keck Center have identified urokinase as a major participant in the initial stages of tumor development. Recent studies of the anticoagulant Protein C pathway, have demonstrated that this system may serve as a new therapeutic target for arresting not only ulcerative colitis but also the incidence of colorectal cancer.
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Papers共 468 篇Author StatisticsCo-AuthorSimilar Experts
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Johanna Olesk,Deborah Donahue,Jessica Ross, Conor Sheehan, Zach Bennett, Kevin Armknecht, Carlie Kudary,Juliane Hopf,Victoria A. Ploplis,Francis J. Castellino,Shaun W. Lee,Prakash D. Nallathamby
NANOSCALE ADVANCESno. 4 (2024): 1145-1162
Armando M Marrufo, Jonathan J Molina, Chris Gager,Marissa J Andersen, Alyssa A LaBella, Elizabeth R Lucas, Ellsa Wongso, Tamanna Urmi, Kassandra Arias-Parbul, Railyn Webster,Peter V Stuckey, Kurt N Kohler,
bioRxiv : the preprint server for biology (2024)
Jonathan J Molina, Kurt N Kohler, Christopher Gager,Marissa J Andersen, Ellsa Wongso, Elizabeth R Lucas, Andrew Paik,Wei Xu,Deborah L Donahue,Karla Bergeron,Aleksandra Klim,Michael G Caparon,
Research squareno. 1 (2023): 1-16
Henry M. Vu,Zhong Liang,Yun-Juan Bao, Paulina G. Carles, Jessica C. Keane,Madelyn G. Cerney,Caitlyn N. Dahnke,Ana L. Flores-Mireles,Victoria A. Ploplis,Francis J. Castellino,Shaun W. Lee
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Journal of thrombosis and haemostasis : JTHno. 6 (2023): 1630-1635
A Dushani C U Ranasinghe, Maggie Holohan,Kalyn M Borger,Deborah L Donahue,Rafael D Kuc, Martin Gerig, Andrew Kim,Victoria A Ploplis,Francis J Castellino,Margaret A Schwarz
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Author Statistics
#Papers: 467
#Citation: 17791
H-Index: 69
G-Index: 111
Sociability: 7
Diversity: 0
Activity: 1
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