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个人简介
e has a distinguished career researching environmentally induced birth defects. Dr. Finnell serves on the National Advisory Environmental Health Sciences Council and is the chair of the CICbioGUNE Research Institute scientific advisory board in Bilbao, Spain, where he also holds a research appointment.
Research Interests
Research in Dr. Finnell's laboratory focuses on the interaction between specific genes and nutritional factors as they influence normal embryonic development. The laboratory is primarily engaged in understanding the beneficial effects of women taking a multivitamin containing the B vitamin folic acid. We want to know how it protects developing babies from having birth defects, and why it is not effective in some pregnancies. The laboratory participates in the National Birth Defects Prevention Study as a core laboratory, serving the needs of Texas, California and Massachusetts. In additional to performing population based human molecular epidemiology studies, the Finnell Laboratory uses the latest in gene knockout technology to eliminate the function of genes to create novel mouse models of human diseases.
The goal of the work is to develop better means of identifying high-risk pregnancies and to optimize the use of nutritional factors to prevent preventable birth defects without causing unintended adverse health effects on the population at large. Enhanced capabilities for assessment of individual risk for developing spina bifida and other folate responsive birth defects would permit prevention regimens to be tailored to individuals rather than applied 'shot-gun' to populations. In broadest scope, our research efforts have implications for every reproductive-age woman worldwide. In addition, folate metabolism can exert a lasting impact on gene expression by influencing DNA methylation, making it imperative that we understand the ramifications of folic acid supplementation. Understanding the relationships between the folic acid metabolic pathway and risk genes associated with birth defects will have important relevance for a broad range of other diseases such as autism, in which folate status may play a significant role.
Research Interests
Research in Dr. Finnell's laboratory focuses on the interaction between specific genes and nutritional factors as they influence normal embryonic development. The laboratory is primarily engaged in understanding the beneficial effects of women taking a multivitamin containing the B vitamin folic acid. We want to know how it protects developing babies from having birth defects, and why it is not effective in some pregnancies. The laboratory participates in the National Birth Defects Prevention Study as a core laboratory, serving the needs of Texas, California and Massachusetts. In additional to performing population based human molecular epidemiology studies, the Finnell Laboratory uses the latest in gene knockout technology to eliminate the function of genes to create novel mouse models of human diseases.
The goal of the work is to develop better means of identifying high-risk pregnancies and to optimize the use of nutritional factors to prevent preventable birth defects without causing unintended adverse health effects on the population at large. Enhanced capabilities for assessment of individual risk for developing spina bifida and other folate responsive birth defects would permit prevention regimens to be tailored to individuals rather than applied 'shot-gun' to populations. In broadest scope, our research efforts have implications for every reproductive-age woman worldwide. In addition, folate metabolism can exert a lasting impact on gene expression by influencing DNA methylation, making it imperative that we understand the ramifications of folic acid supplementation. Understanding the relationships between the folic acid metabolic pathway and risk genes associated with birth defects will have important relevance for a broad range of other diseases such as autism, in which folate status may play a significant role.
研究兴趣
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Maayke A de Koning, Paula A Pimienta Ramirez,Monique C Haak, Xiao Han, Martina Ha Ruiterkamp-Versteeg,Nicole de Leeuw,Ulrich A Schatz,Moneef Shoukier,Esther Rieger-Fackeldey,Javier U Ortiz,Sjoerd G van Duinen,Willemijn M Klein,
Journal of medical genetics (2024)
Salvatore Vaiasicca, Gianmarco Melone,David W James,Marcos Quintela, Jing Xiao,Seydou Yao,Richard H Finnell, Robert S Conlan,Lewis W Francis,Bruna Corradetti
Stem cells translational medicine (2024)
FASEB JOURNALno. 1 (2024): e23346-e23346
Lei Lu,Meizhu Bai,Yufang Zheng,Xiukun Wang,Zhongzhong Chen,Rui Peng,Richard H. Finnell,Tongjin Zhao, Chengtao Li, Bo Wu,Yunping Lei,Jinsong Li,
Science Bulletin (2024)
Genetics in Medicine Open (2024): 101044
Current Stem Cell Reportspp.1-10, (2024)
Pediatric Researchno. 4 (2024): 880-882
Bernard K. van der Veer, Lehua Chen, Spyridon Champeris Tsaniras, Wannes Brangers,Qiuying Chen, Mariana Schroiff, Colin Custers, Harm H.M. Kwak,Rita Khoueiry,Robert Cabrera,Steven S. Gross,Richard H. Finnell,
biorxiv(2024)
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