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个人简介
2002年在清华大学生命科学学院获得理学学士学位,2007年在清华大学医学院获得理学博士学位,2009年在美国国立卫生研究院完成博士后工作,从事膜蛋白结构与功能研究,包括信号传导中的GPCR受体蛋白及其相关蛋白复合物,GPCR和Agonist/Antagonist的相互作用等。在研究工作中共测定了11个蛋白质及其复合物的晶体结构,在SCI收录的国外期刊上发表论文17篇,参与编写清华大学教科书1本。2009年12月回国工作,主要研究方向为靶向药物筛选与设计,计算生物学和结构生物学,通过测定药物靶点蛋白的结构,分析蛋白与小分子配体的结合机制,进而设计优化潜在的药物分子,参与具有自主知识产权的新药研究。[1] Bell SG, Xu F†, Johnson EO, Forward IM, Bartlam M, Rao Z, Wong LL.
Protein Recognition in Ferredoxin–P450 Electron Transfer in the Class I CYP199A2 System from Rhodopseudomonas palustris. Journal of Biological Inorganic Chemistry; 2009 Nov 11.
[2] Xu F, Bell SG, Peng Y, Johnson EO, Bartlam M, Rao Z, Wong LL. Crystal structure of a ferredoxin reductase for the CYP199A2 system from Rhodopseudomonas palustris. Proteins. 2009 Dec; 77(4):867-80.
[3] Bell SG, Xu F†, Forward I, Bartlam M, Rao Z, Wong LL. Crystal structure of CYP199A2, a para-substituted benzoic acid oxidizing cytochrome P450 from Rhodopseudomonas palustris. J. Mol. Biol. 2008 Nov 14; 383(3):561-74.
[4] Li L, Liu X, Yang W, Xu F, Wang W, Feng L, Bartlam M, Wang L, Rao Z. Crystal structure of long-chain alkane monooxygenase (LadA) in complex with coenzyme FMN: unveiling the long-chain alkane hydroxylase. J Mol Biol. 2008 Feb 15; 376(2):453-65.
[5] Guo D, Xu F, Bell SG, Pang X, Bartlam M, Wong LL. Purification, crystallization and preliminary crystallographic analysis of CYP 195A2, a P450 enzyme from Rhodopseudomonas palustris. Protein Pept Lett. 2008; 15(4):423-6.
[6] Xu F, Bell SG, Rao Z, Wong LL. Structure–activity correlations in pentachlorobenzene oxidation by engineered cytochrome P450cam. Protein Eng. Des. Sel. 2007 Oct; 20(10):473-80.
[7] Peng Y, Xu F‡, Bell SG, Wong LL, Rao Z. Crystallization and preliminary X-ray diffraction studies of a ferredoxin reductase from Rhodopseudomonas palustris CGA009. Acta Crystallographica Section F. 2007; 63(Pt5):422-5.
[8] Pang X, Xu F‡, Bell SG, Guo D, Wong LL, Rao Z. Preliminary Crystallographic Analysis of Cytochrome P450 203A1 from Rhodopseudomonas palustris. Acta Crystallographica Section F. 2007; 63(Pt4):342-5.
[9] Zhao Q, Qin L, Jiang F, Wu B, Yue W, Xu F, Rong Z, Yuan H, Xie X, Gao Y, Bai C, Bartlam M, Pei X, Rao Z. Structure of human spindlin1: tandem tudor-like domains for cell cycle regulation. J Biol Chem. 2007 Jan 5; 282(1):647-56.
[10] Bell SG, Hoskins N, Xu F, Caprotti D, Rao Z, Wong LL. Cytochrome P450 enzymes from the metabolically diverse bacterium. Rhodopseudomonas palustris. Biochem Biophys Res Commun. 2006 Mar 31; 342(1):191-6.
[11] Dong X, Xu F, Gong Y, Gao J, Lin P, Chen T, Pen Y, Qiang B, Yuan J, Peng X, Rao Z. Crystal structure of the V domain of human Nectin-like molecule-1/SynCAM3 /TSLL1/IGSF4B, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule. J Biol Chem. 2006 Apr 14; 281(15):10610-7.
[12] Xu F, Bell SG, Lednik J, Insley A, Rao Z, Wong LL. The heme monooxygenase cytochrome P450cam can be engineered to oxidize ethane to ethanol. Angew Chem Int Ed Engl. 2005 Jun 27; 44(26):4029-32.
[13] Dong X, Peng Y, Peng Y, Xu F, He X, Wang F, Peng X, Qiang B, Yuan J, Rao Z. Characterization and crystallization of human DPY-30-like protein, an essential component of dosage compensation complex.Biochim Biophys Acta. 2005 Dec 1; 1753(2):257-62.
[14] Wang YY, Zhou GB, Yin T, Chen B, Shi JY, Liang WX, Jin XL, You JH, Yang G, Shen ZX, Chen J, Xiong SM, Chen GQ, Xu F, Liu YW, Chen Z, Chen SJ. AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implycation in stepwise leukemogenesis and response to Gleevec. Proc Natl Acad Sci U S A. 2005 Jan 25; 102(4):1104-9.
[15] Yu B, Duan M, Zhou G, Chen J, Xu F. Practice of Experimental Biochemistry. Tsinghua University Press, 2004, ISBN 7-302-07519-0/Q.35
[16] Bell SG, Chen X, Xu F, Rao Z, Wong LL. Engineering substrate recognition in catalysis by cytochrome P450cam. Biochem Soc Trans. 2003 Jun; 31(Pt 3):558-62.
[17] Bell SG, Chen X, Sowden RJ, Xu F, Williams JN, Wong LL, Rao Z. Molecular recognition in (+)-alpha-pinene oxidation by cytochrome P450cam. J Am Chem Soc. 2003 Jan 22; 125(3):705-14.
[18] Chen X, Christopher A, Jones JP, Bell SG, Guo Q, Xu F, Rao Z, Wong LL. Crystal structure of the F87W/Y96F/V247L mutant of cytochrome P-450cam with 1,3,5-trichlorobenzene bound and further protein engineering for the oxidation of pentachlorobenzene and hexachlorobenzene. J Biol Chem. 2002 Oct 4; 277(40):37519-26.
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