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Bio
My research is focused on heart development and cardiovascular diseases, especially congenital heart defects and dilated cardiomyopathy. I got my Ph.D. in Cell Biology from the University of Chinese Academy of Sciences (UCAS), during which time my research was focused on the mechanisms underlying heart failure syndrome induced by hyperglycemia. After that, I became a postdoctoral associate at the University of Pittsburgh, where I am now using state-of-the-art techniques such as single-cell mRNA sequencing and cardiac organoid system to understand human heart development and model several specific types of congenital heart defects. Through the past several years of scientific research training, I have uncovered a new potential therapeutic gene target to treat diabetic cardiomyopathy and established an advanced pipeline to model congenital heart defects by the combination of somatic reprogramming, heart organoid system, single-cell mRNA sequencing as well as machine learning methods. My long-term goal is to understand the cellular and molecular mechanisms underlying congenital heart defects and inherited cardiomyopathies.
Research Interests
Papers共 162 篇Author StatisticsCo-AuthorSimilar Experts
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Shao-Hua Zhang, Li He,Jian-Zhao Duan,Shao-Long Zang,Tian-Cong Yang,U. R. S. Schulthess,Tian-Cai Guo, Chen-Yang Wang,Wei Feng
Precision Agricultureno. 1 (2024): 119-145
Computers and Electronics in Agriculture (2024): 109022
Shaohua Zhang, Xinghui Qi, Mengyuan Gao,Changjun Dai,Guihong Yin,Dongyun Ma,Wei Feng,Tiancai Guo, Li He
Food Chemistry (2024): 139103-139103
Acta Agronomica Sinicano. 2 (2023)
Remote. Sens.no. 10 (2023): 2513-2513
ECOLOGICAL INDICATORS (2023): 110750-110750
chinaxiv(2023)
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Ecological Indicators (2023): 110781
Scientia Agricultura Sinicano. 9 (2023)
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